Project Grant 2543709
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $406,250 on March 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance nucleic acid chemistry and synthetic biology for RNA therapeutics. The research program develops de novo xeno nucleic acids (XNAs)—synthetic nucleic acid analogs with modified backbones that enhance nuclease resistance and extend half-life—to expand the genetic toolkit for RNA silencing and...
- The National Science Foundation Division of Chemistry awarded the University of Pennsylvania $650,000 on August 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to investigate biosynthetic pathways and establish new chemical synthesis methodology. Dr. Dirk Trauner will study how living organisms build complex molecules and apply those insights to develop efficient synthetic routes for biologically active compounds. The research focuses on biosynthetically inspired...
- This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
- This $360,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The project aims to develop new peptide nucleic acid (PNA) molecules capable of selectively recognizing and binding to double-stranded non-coding RNA. This research addresses an important challenge in RNA biochemistry and could enable...
- The National Science Foundation Division of Chemistry awarded a $275,000 Project Grant to The Trustees of the University of Pennsylvania under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support collaborative research controlling nanoscale self-assembly via binding-induced polarization. Over the three-year period from August 2022 to July 2025, researchers from Penn State University and the University of Pennsylvania will investigate the impact of Lewis acid-base...
- This federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research by professors Eriks Rozners of SUNY at Binghamton and James A. Mackay of Elizabethtown College. The $465,000 grant, awarded on August 15, 2024, focuses on developing new peptide nucleic acid (PNA) nucleobases capable of sequence-selective recognition of non-coding RNA. The research aims to uncover new methods for molecular...
- The National Science Foundation awarded North Carolina State University $525,836 under the Mathematical and Physical Sciences program (CFDA 47.049) for a three-year project grant completing July 2025. The university will research self-organizing nucleic acid supramolecular assemblies with stimuli-responsive properties. Specifically, the project aims to develop a toolkit for constructing responsive nanoparticle-based materials using rationally designed RNAs as modular building blocks. Researchers...
- The National Science Foundation (NSF) awarded a $600,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Wisconsin-Madison to advance DNA-encoded chemical library (DECL) technology. Over the 3-year period from May 1, 2025 to April 30, 2028, Professors Jennifer Schomaker and Jeffrey Martell, along with Dr. Jing Chai from GlaxoSmithKline, will develop mild oxidative reactions to preserve the integrity of DNA tags in DECL synthesis. This will...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
- The National Science Foundation Division of Materials Research awarded The Pennsylvania State University four hundred fifty thousand dollars on August 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop enzyme-powered active particle populations with distributed functionality. The research designs intelligent systems of communicating particle populations that perform different tasks in concert. In the proposed swarm-based detection and response system, seeker...
The National Science Foundation Division of Chemistry awarded the University of Pennsylvania $497,504 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop biotechnology platforms based on synthetic genetic polymers known as xeno nucleic acids (XNAs) for protein recognition and aggregation control. The research team will establish two complementary XNA-SELEX (in vitro evolution) platforms to identify functional XNAs capable of selectively interacting with proteins involved in aggregation, using the aggregation-prone RNA-binding protein FUS as a model system. Investigators will conduct biochemical and biophysical analyses to determine how synthetic nucleic acids influence protein recognition, liquid-liquid phase separation, and protein aggregation. The work addresses the gap in existing molecular tools for investigating and controlling disease-related protein aggregation associated with neurodegenerative disorders and other human diseases, leveraging the enhanced chemical stability and unique structural properties of XNAs compared to natural nucleic acids. The project integrates research with education through training of graduate and undergraduate students, K-12 outreach activities, publicly accessible educational resources, and workshops designed to broaden participation in nucleic acid chemistry and synthetic biology. Performance occurs in Philadelphia, Pennsylvania, with an ultimate completion date of July 31, 2031. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $497.5k | 8/14/26 |