Project Grant 2541725
- This two-year project grant from the National Science Foundation's Computer and Information Science and Engineering program aims to develop deep learning methods for high-resolution three-dimensional genome structure spatial reconstruction. With a total funding amount of $175,000, the award was issued on May 1, 2022 to the University of Colorado Colorado Springs to complete the project by April 30, 2024. The grantee will apply sophisticated and automated deep learning approaches to infer...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Indiana University to investigate the role of epigenetic mechanisms in regulating gene expression programs during the development of the cerebral cortex in mammals. The project aims to elucidate how specific histone modifications influence neurogenesis and cell fate specification, with the goal of enhancing fundamental understanding of mammalian, including...
- This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $127,145 to The Trustees of Princeton University to conduct research dedicated to unraveling the regulatory mechanisms governing chromatin organization and gene transcription during neural development in the Drosophila model organism. The primary focus is on understanding how...
- This $292,727 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports a research project by The Broad Institute, Inc. to discover novel regulators of 3D genome organization. The project aims to leverage large-scale genomic datasets to predict and experimentally validate new trans-acting factors that regulate chromatin interactions and genome architecture. By applying deep neural network models to in silico genetic...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- This federal Project Grant award of $899,982 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research effort to study X-chromosome inactivation and genome organization in human cells. The research team from New York University, Harvard University, and the New Mexico Consortium will integrate advanced genomics data, computational modeling, and biophysical approaches to unravel the complex folding of the X-chromosome and its impact on...
- This Project Grant award, provided by the National Science Foundation's Office of Multidisciplinary Activities under CFDA Program 47.075 - Social, Behavioral, and Economic Sciences, supports an early-career scientist's postdoctoral fellowship to study how childhood experiences shape brain development during adolescence. The $160,000 award, effective from September 1, 2025 to August 31, 2027, will fund research to characterize the links between childhood environment and cortical...
- This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
This Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), will support research to investigate how the three-dimensional organization of the human genome controls gene expression and cell identity in the brain. The $300,000 award, spanning August 2025 to July 2027, will fund the development of new AI-powered tools to reconstruct 3D chromosome structure from single-cell experiments and simulate how changes in genome structure affect gene activity. The goal is to create detailed maps of chromatin structure across different brain cell types and computational models to explain how genetic information is interpreted differently in various cells. The project will generate community resources such as open-source software and public data releases, as well as provide training opportunities for early-career researchers. The results are expected to advance understanding of brain development and disease, and guide future genome editing interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 8/6/25 |