Project Grant 2539770
- The National Science Foundation (NSF) Division of Integrative Organismal Systems awarded a 4-year, $2,670,305 Project Grant titled "TRTECH-PGR: REPROGRAMMING THE PLANT CELL WITH TRANSCRIPTION FACTORS" under the Biological Sciences federal grant program (CFDA 47.074). This project aims to systematically assess the effects of ectopically expressing thousands of maize transcription factors on gene expression and physiological responses in plant tissues. The research will use...
- The National Science Foundation awarded a $1.5 million Project Grant to Michigan State University under the Biological Sciences federal grant program (CFDA 47.074) for the period of May 15, 2021 through April 30, 2025. The grant funds the TRTECH-PGR: MAIZE HUB project to develop an open-source simulation platform and resources integrating extensive field trial data, DNA sequences, and historical weather records for maize. The University of Wisconsin System will receive a sub-award as part of the...
- This three-year, $1.8 million project grant from the National Science Foundation Division of Integrative Organismal Systems aims to develop rapid transformation and gene editing techniques in maize through the Biological Sciences program (CFDA 47.074). The University of Missouri System will work to establish a system for precisely inserting transgenes and editing genes at predetermined sites in the genome of maize. Researchers will create "landing pads" on five chromosomes of a...
- This $1,999,998 National Science Foundation Project Grant, funded under the Biological Sciences program (CFDA 47.074), supports research at the University of Washington to advance plant synthetic biology through deciphering the grammar of crop gene regulatory elements. The three-year award beginning March 1, 2023 will apply massively parallel reporter assays and machine learning to characterize tens of thousands of genetic regulatory elements in maize and tomato, including enhancers,...
- This federal Project Grant award of $1,192,499.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research by the Donald Danforth Plant Science Center in Missouri to develop epigenetic editing tools for crop improvement. The key objectives of this 4-year project are to: 1) Expand epigenetic editing technologies to other crop species beyond cassava, such as rice and tomato, to enable disease resistance; 2) Demonstrate additional applications of...
- This $735,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support research at Cornell University to investigate the interactions of plant transcription factors that regulate the three-dimensional patterning of grass leaves. The research aims to gain a better understanding of the functional interactions between the LIG1 and WOX3 transcription factor genes, which are critical for determining leaf width, length, and angle in grasses like...
- This Project Grant award of $968,613 from the National Science Foundation Division of Molecular and Cellular Biosciences supports research into developing a novel CRISPR synthetic biology tool for investigating and reprogramming alkaloid biosynthesis regulation in Catharanthus roseus. The award was made on March 1, 2021 to Northeastern University for work to be completed by December 31, 2024 under the Biological Sciences program (CFDA 47.074). A sub-award of $100,000 was also provided to...
- This federal Project Grant award of $603,307 from the National Science Foundation's Biological Sciences program (CFDA 47.074) aims to identify the genetic mechanisms that control plant-microbiome interactions in the model legume Medicago truncatula. The five-year project (3/1/2025 - 2/28/2030) will leverage Medicago's extensive resources to map the genetic basis of microbiome variation and validate the functional significance of candidate genes. It will also examine connections between known...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $649,999 to Duke University to conduct collaborative research on transcription factor binding sites in plant organ formation. The goal is to create a semi-automated system to analyze gene activity across different plant organ types, such as roots, leaves, and flowers. The research will compare two plant species, define the role of a cell signaling pathway on gene function in...
- Michigan State University was awarded a $639,998 Project Grant from the National Science Foundation Division of Integrative Organismal Systems to conduct collaborative research from July 1, 2023 through June 30, 2027. The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote biological sciences research and enhance understanding of major national problems. Under this award, the university will use mathematical approaches from topological data analysis to...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program provides funding to Michigan State University for the "DECODING MAIZE TRANSCRIPTION FACTOR-MEDIATOR INTERACTIONS: A BREAKTHROUGH TOOL FOR PRECISION GENE REGULATION" project. The $299,466 award aims to develop a novel synthetic biology platform, called "Mediator-Engineered Regulator Interaction Tuning (MERIT)", that enables precise, programmable control of gene expression in maize. The key objectives are to elucidate the interactions between maize transcription factors and the Mediator complex, a central regulator of transcription, and then leverage this knowledge to engineer modified transcription factors that can precisely control gene expression through rewired interactions with the Mediator complex. If successful, this high-risk, potentially transformative project could provide a breakthrough tool for targeted manipulation of genetic programs in plants and other organisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $299.5k | 8/18/25 |