Project Grant 2031237
- The National Science Foundation (NSF) awarded a $800,000 Project Grant under its Biological Sciences program (CFDA 47.074) to The Regents of the University of California, doing business as University of California, Berkeley. The grant funding will support collaborative research to discover and characterize compact CRISPR gene editing systems that can be encoded in plant viruses. This will enable more efficient and widespread deployment of genome editing capabilities across a variety of crop...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awards $1.1 million to the University of Massachusetts Medical School for a five-year research initiative (August 1, 2025 – July 31, 2030) investigating novel bacterial immune systems as next-generation genome editing tools. The research will deliver scientific products through systematic investigation of the DDMDE (DNA-guided, DNA-targeting) bacterial system, which operates independently of PAM (Protospacer...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $429,656.00 to Cornell University to conduct research using synthetic biology methods to engineer microorganisms to produce valuable plant natural products. The key objectives are to reconstitute plant biosynthetic machinery in yeast in order to better understand and harness plant enzyme complexes for natural product synthesis. This research aims to develop a more resilient...
- The National Science Foundation's Biological Sciences program awarded a $1,200,000 project grant to the University of California, Los Angeles (UCLA) Office of Research Administration to discover and characterize small CRISPR genome editing systems for virus-based delivery into plants. This 3-year project aims to develop new tools to enhance plant breeding and create crops with higher yields, drought resistance, and pest/temperature tolerance. The work includes screening metagenomic data to...
- This $725,512 project grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop highly efficient and robust prime editing systems in rice, tomato, and poplar plants. Prime editing is an advanced CRISPR/Cas gene editing technology that enables precise gene modifications, offering significant advantages over conventional CRISPR approaches. The project will optimize prime editor proteins, improve prime editor guide RNA structures and...
- This $1,000,000.00 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to characterize the molecular mechanisms by which the bridge helix (BH) region of the CRISPR-associated (Cas) 9 and Cas12a enzymes contributes to DNA cleavage fidelity. The overarching goal is to develop error-proof variants of these genome editing tools that minimize unintended off-target DNA modifications. The award includes a sub-grant to the University...
- The University of Maryland, College Park was awarded a $1,205,836 Project Grant from the National Science Foundation Division of Integrative Organismal Systems under the Biological Sciences federal grant program (CFDA 47.074) for the period of March 1, 2022 through February 28, 2025. The grant funds the development of highly efficient and unconstrained CRISPR systems for plant functional genomics. Specifically, the University will utilize the funding to advance CRISPR technology for analyzing...
- This $322,020 Project Grant award from the National Science Foundation's (NSF) Division of Integrative Organismal Systems will support collaborative research at the University of California, Davis (UC Davis) to develop improved methods for CRISPR/Cas9-based gene editing in maize. The key objectives are to generate maize lines expressing high levels of Cas9 nuclease and to engineer and optimize viral vectors to efficiently deliver guide RNAs for both somatic and heritable gene editing. This...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded The Johns Hopkins University a $480K Project Grant (CFDA 47.074 – Biological Sciences) effective March 1, 2025, through February 28, 2030, to conduct fundamental research exploring novel interactions between CRISPR-Cas systems and temperate bacteriophages. The research will investigate how bacterial CRISPR-Cas9 immunity systems acquire and utilize "memory" of prior...
- This $1,211,545 Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) will support the development of advanced Prime Editing (PE) systems in rice, tomato, and poplar plants. Prime Editing is a novel and highly versatile CRISPR-based gene editing technology that enables precise genome modifications. The key objectives of this 3-year project are to optimize Prime Editor proteins to increase their activity and editing efficiency, improve pegRNA structure and...
This Project Grant award of $968,613 from the National Science Foundation Division of Molecular and Cellular Biosciences supports research into developing a novel CRISPR synthetic biology tool for investigating and reprogramming alkaloid biosynthesis regulation in Catharanthus roseus. The award was made on March 1, 2021 to Northeastern University for work to be completed by December 31, 2024 under the Biological Sciences program (CFDA 47.074). A sub-award of $100,000 was also provided to Michigan State University to support this research. The Biological Sciences program aims to advance fundamental knowledge in biology and strengthen the nation's scientific enterprise. This award directly supports those goals through development of new CRISPR techniques that will provide insights into specialized metabolite production in an important medicinal plant species and allow reprogramming of those pathways.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $150.5k | 12/6/22 | ||
| Not listed | $0 | 5/19/21 | ||
| Not listed | $818.1k | 2/25/21 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
50293478050S | Michigan State University | Project Grant 2031237 | $85.2k | 3/1/21 |