Project Grant 2532798
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $410,939 to Clemson University to conduct research on the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, specifically atomic force microscopy, to study how membrane proteins interact with cell membranes and maintain their proper structure. The goal is to gain fundamental biophysical...
- This federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) totaling $460,149 provides funding to the University of Massachusetts to develop photoswitchable lipid bilayer membranes that mimic the functions of cell membranes. The 3-year project, with a performance period from September 1, 2025 to August 31, 2028, aims to fabricate and characterize these synthetic membranes that can undergo dynamic shape changes, fluid...
- This National Science Foundation (NSF) project grant under the Mathematical and Physical Sciences program (CFDA 47.049) will develop and characterize enzyme-loaded protein vesicles that can partition hydrophobic substrates and products to improve the sustainability of industrial biocatalysis. The $503,611 award to the Georgia Tech Research Corporation will (1) create pH-responsive vesicles containing a dehalogenase enzyme, (2) assess partitioning of substrates with varying hydrophobicity into...
- This National Science Foundation project grant of $500,000 will fund research at the University of California, Santa Barbara to study the assembly, disassembly, and mechanics of porous colloidal vesicles from April 15, 2023 to March 31, 2026. The research aims to advance understanding of fundamental processes involved in vesicle formation that are relevant across fields including physics, biology, engineering, and materials science. The university researchers will utilize state-of-the-art...
- This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems award of $234,000 to the University of Illinois will support collaborative research on developing an active lipid vesicle-based drug delivery system. The project aims to accomplish three key objectives: 1) examine the directed motion of lipid vesicles driven by encapsulated self-propelled particles, 2) develop a non-contact photoreaction mechanism to induce rupture and controlled...
- This $208,784 federal Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project to study the emergent dynamics and scaling laws of bioinspired lipid membranes. The University of Arizona, as the primary awardee, will integrate experimental methods such as neutron spectroscopy, NMR, and flicker spectroscopy with molecular dynamics simulations. This integrated approach aims to establish the...
- The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
- The National Science Foundation Division of Materials Research awarded a $438,521 project grant to the Georgia Tech Research Corporation from July 1, 2021 to June 30, 2024. The grant supports research titled "Engineering Responsive Chemical Heterogeneity in Protein Vesicles for Simultaneous Delivery of Diverse Cargoes" under the Mathematical and Physical Sciences program (CFDA 47.049). The research aims to develop protein vesicle delivery systems that can encapsulate and release...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will support the development of new biomanufacturing methods to produce extracellular vesicles (EVs) accurately, consistently, and at scale. The $249,950 project, awarded to the University of Alabama, aims to address key challenges in EV production and characterization to advance the use of EVs in drug delivery and regenerative medicine. The two-year effort will...
This Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program provides $507,298 to the University of Florida to conduct fundamental research on developing artificial protein-based vesicles that can mimic natural cell membrane structures and signaling functions. The goal is to create new biomaterial systems that can reliably control the organization and presentation of surface proteins, which is critical for activating immune responses, such as in cancer immunotherapies. This 3-year project supports the development of innovative protein engineering and self-assembly approaches to design vesicles that behave like simplified cell membranes, enabling researchers to program how surface proteins interact. The broader impacts include providing research experiences for undergraduate and high school students, integrating lab modules into courses, and creating outreach activities to introduce young learners to biomolecular engineering and synthetic biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $507.3k | 12/31/25 |