This Project Grant award of $1,272,751 from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support research at The Ohio State University to develop new experimental methods, protocols, and analysis software for characterizing proteins at the atomic level using nuclear magnetic resonance (NMR) spectroscopy. The primary goals are to make NMR more accessible to both experts and non-experts through standardized workflows and free, AI/ML-enhanced software for automation and quantitative analysis. The research will explore new NMR techniques like nanoparticle-assisted nuclear spin relaxation to gain insights into protein structural dynamics and function. The project will also leverage molecular dynamics simulations and machine learning to generate physically realistic conformational ensembles of proteins and their binding partners. This award aims to advance the fundamental understanding of protein structure, dynamics, and interactions, with potential applications in fields like molecular biology, biochemistry, and structural biology.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.3m | 7/9/25 |