Project Grant 2530676
- This $480,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of novel approaches for assembling three-dimensional protein biomaterials. The primary goal is to create "coordinated protein frameworks" (CPFs) - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This work leverages non-canonical amino acids to precisely control the...
- This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
- The National Science Foundation awarded a $599,940 Project Grant to the University of Chicago under the Mathematical and Physical Sciences program (CFDA 47.049) for research titled "COLLABORATIVE RESEARCH: DMREF: GOALI: HIGH-AFFINITY SUPRAMOLECULAR PEPTIDE MATERIALS FOR SELECTIVE CAPTURE AND RECOVERY OF PROTEINS." The four-year award beginning October 1, 2021 will support the development of new high-affinity supramolecular peptide materials for selective capture and recovery of...
- This Project Grant award for $140,390 was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports research to develop porous peptide frameworks inspired by the modular architecture of proteins. The research aims to engineer these frameworks by appending peptides with aromatic π-stackers to guide the predictable self-assembly of the peptides into sophisticated porous materials. If successful, these...
- This $232,771 Project Grant, awarded on September 15, 2025, was provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The grant aims to develop computational mathematical tools to better understand protein structures and interactions, even across a wide range of mutations. This interdisciplinary research combines mathematical modeling, machine learning, and biology to analyze the complex shapes of proteins, with the goal of enabling...
- This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $100,000 will support collaborative research to develop deep learning-based "consistency models" that can simulate protein dynamics over long time scales. The goal is to overcome the limitations of current molecular dynamics simulation methods, which are constrained by the need for tiny time steps, in order to unlock new insights into protein behavior and...
- This $486,845 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports Professor Xiaolin Cheng of Ohio State University in developing computational tools and a theoretical framework for analyzing allosteric regulation in proteins. The research aims to advance the fundamental understanding of allosteric modulation, a key mechanism of protein function and regulation with significant implications for drug discovery. The...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $410,939 to Clemson University to conduct research on the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, specifically atomic force microscopy, to study how membrane proteins interact with cell membranes and maintain their proper structure. The goal is to gain fundamental biophysical...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research conducted by Dr. Ao Ma at the University of Illinois Chicago aimed at understanding the mechanisms behind how proteins bind small molecules. The $540,000 award, with a period of performance from September 1, 2025 to August 31, 2028, will use novel computational methods to reveal the step-by-step pathways and driving forces behind ligand binding. The research focuses on two model systems, HIV-1 protease and PDZ domains, to study how protein conformational changes and water dynamics collectively control ligand binding. The work is expected to advance the understanding of enzyme function and inform the design of more effective drugs. In addition, the project will enhance education and training through graduate curriculum development, undergraduate research participation, and high school student mentorship.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $540.0k | 8/25/25 |