Project Grant 2528383
- The U.S. National Science Foundation (NSF) awarded a $426,000 project grant under the Mathematical and Physical Sciences (CFDA 47.049) program to The Regents of the University of California, San Francisco (UCSF) to conduct collaborative research on developing novel protein-based materials for photosynthetic energy transduction. The multi-year project, led by Professors Michael Therien and David Beratan of Duke University and William DeGrado of UCSF, aims to design and construct protein-based...
- Duke University was awarded an $840,000 project grant from the National Science Foundation to conduct collaborative research on de novo protein constructs for photosynthetic energy transduction from November 1, 2021 to October 31, 2024. The award is being administered under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these scientific fields and strengthen the nation's scientific enterprise through increasing knowledge and enhancing...
- The Regents of the University of California, San Francisco received a three-year, $374,994 Project Grant from the National Science Foundation Division of Chemistry. The grant supports collaborative research titled "De Novo Protein Constructs for Photosynthetic Energy Transduction" under the Mathematical and Physical Sciences program (CFDA 47.049). The research aims to advance understanding of major problems in photosynthesis through increasing the store of scientific knowledge on de...
- This $480,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of novel approaches for assembling three-dimensional protein biomaterials. The primary goal is to create "coordinated protein frameworks" (CPFs) - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This work leverages non-canonical amino acids to precisely control the...
- This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
- This $500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will fund Dr. Nicholas Truex at the University of South Carolina to investigate synthetic protein switches. The research aims to characterize the molecular interactions that enable these proteins to adopt two distinct folded structures, utilizing non-natural amino acids to dissect their conformation and stability. Key experimental techniques will include...
- This Project Grant award of $1,500,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research to elucidate the design principles for de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key products and services to be delivered include: (1) Development of de novo designed proteins that can be readily transformed into junctions within polymer networks. (2) Investigation of the use of de novo...
- This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to...
- This $1,500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program will support research at Northwestern University to develop innovative protein-based biomaterials. The research aims to (1) engineer mussel foot proteins with superior underwater adhesive properties compared to wild-type sequences, and (2) create resilin-inspired bioelastomers with high strength while retaining natural mechanical resilience. The proposed...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
This Project Grant award of $924,000.00 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by Professors Michael Therien and David Beratan of Duke University and Professor William DeGrado of the University of California San Francisco. The goal of this research is to develop new protein-based materials capable of harvesting, storing, and releasing energy in ways that mimic the sophisticated energy transduction processes observed in nature. The project will leverage recent advances in protein design to create novel optical, electrical, and chemical systems with functions not found in natural biological systems. This research will provide specialized training for graduate students and postdoctoral fellows in areas such as synthetic chemistry, protein design, biochemistry, computational methods, and techniques to monitor fast charge and energy transfer processes. The project also includes outreach activities to introduce college and pre-college students to these emerging technologies and related career paths in science and engineering.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $924.0k | 8/20/25 |