Project Grant 2527994
- This National Science Foundation (NSF) CAREER: Peristalsis Mechanobiology in the Uterine Endometrium project grant, under CFDA 47.041 - Engineering, will support research into how the movement of the uterus, called peristalsis, affects the cells in its inner lining. The $649,961 award to the Texas A&M Engineering Experiment Station (Tees) aims to investigate how uterine mechanics transduce into endometrial cell responses like growth, migration, and immune activation using a specialized...
- This $250,120 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports collaborative research at Clemson University to investigate the effects of physical deformation on the proliferation and motility of single cells. The goal is to develop specialized microfluidic devices to simulate the tight spaces cells experience in the human body and study how physical stresses impact cellular behaviors like division and movement. This research...
- This $600,000 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) aims to develop new engineering tools to better understand the interactions between biological and mechanical signals in the body. The research focuses on investigating how exposure to endocrine-disrupting chemicals may affect fertility and pregnancy, by integrating spatial omics, protein profiling, and mechanical/imaging data. Key products to be developed include a multi-scale framework...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This $995,498 National Science Foundation project grant supports research at the University of California, Los Angeles to advance knowledge of cellular mechanobiology and translate findings for sustainable protein production. Funded through the NSF's Engineering program (CFDA 47.041), the research aims to understand how cells sense and respond to mechanical stimuli by building a systems-level understanding of the "mechanome." Specific goals include investigating predicted mechanical...
- This $595,934 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will allow Washington State University to develop advanced musculoskeletal models and simulation approaches to investigate the impact of pregnancy on the musculoskeletal system. The research objectives are to: (i) determine how pregnancy and postpartum alter torso and hip muscle mechanical properties, (ii) assess how spine extensors accommodate changes in muscle mechanics and posture during...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $249,894.00 to Syracuse University to study the mechanics of tissue boundary formation through a collaborative research project. The research aims to explain how mechanical forces inside the body shape developing tissues during early stages of life by investigating cell movement, interaction, and the role of mechanical forces in guiding tissue formation. The project combines expertise...
- This Project Grant award of $400,000 from the National Science Foundation's Engineering program (CFDA 47.041) supports a collaborative research effort to study the mechanics of tissue boundary formation during early stages of development. The research aims to explain how mechanical forces inside the body help shape developing tissues and organs. By combining expertise from biology and engineering, the project will advance scientific understanding of tissue formation and potentially lead to new...
- The University of California, Merced received a $200,000 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation on May 15, 2022 to support research under the Engineering program (CFDA 47.041). The award will fund research from May 15, 2022 through April 30, 2024 to develop multi-scale models of cell-matrix mechanical interactions during endothelial cell network assembly. The Engineering program seeks to improve quality of life and...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to quantify the mechanical forces within living cells and determine how changes in these forces impact the production and secretion of proteins that shape the cellular environment. The total funding amount is $297,984.00 and the award period is from February 1, 2025 to January 31, 2028. The research team at the University of Texas Health Science Center at Houston aims to develop...
This $530,601 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to determine the impact of mechanical stretch on the contractility of human uterine smooth muscle cells, as well as the influence of inflammation on these processes. The research team at the University of Southern California will engineer human myometrial smooth muscle cells into aligned microtissues, stretch them to various extents, and analyze changes to their physiology and gene expression to identify potential mechanosensing mechanisms. Additionally, the project will evaluate whether mechanical stretch induces the secretion of pro-inflammatory factors from muscle cells and/or macrophages that activate contractile responses. The goal is to advance fundamental understanding of how both stretch and inflammation regulate uterine contractility, which may inform new therapeutic approaches for pregnancy-related complications. The project will also support the training of graduate and undergraduate students, as well as provide field trip opportunities for local high school students.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $530.6k | 8/22/25 |