The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded $393,106 to Texas A&M Engineering Experiment Station under the Engineering (47.041) federal grant program. The three-year Project Grant will support collaborative experimental and computational research to understand the biomechanics governing epithelial tissue organization and development. Specifically, Texas A&M Engineering Experiment Station will utilize high-resolution imaging and...
This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Worcester Polytechnic Institute (WPI) in the amount of $259,570 will develop 3D spheroid models using patient-derived trophoblast cells to investigate placental cell invasion and study preeclampsia, a pregnancy complication with high global maternal and infant mortality rates. The 2-year project will design culture conditions to maintain the spheroid models, engineer an extracellular matrix to mimic the...
This National Science Foundation (NSF) grant under the Engineering program (CFDA 47.041) provides $297,984 in funding to the University of Texas Health Science Center at Houston to conduct research on quantifying the mechanical forces inside living cells and their impact on cellular behavior. The research aims to develop predictive mechanobiotechnology paradigms to control cell function through externally applied mechanical forces, and create datasets to inform clinical imaging and diagnose...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) project grant, awarded to Worcester Polytechnic Institute (WPI), will develop in vitro models to study fibrosis progression and regression across different tissue types, including the pancreas, skin, and uterine fibroids. The $629,998 award, running from June 1, 2025 to May 31, 2030, will enable WPI to engineer these tissue-specific models to investigate how extracellular matrix properties, cellular composition, and...
This $199,208 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to study the fundamental biomechanics of stomach motility and structure. The research aims to develop a multiscale, physics-based electromechanical modeling framework for stomach function by integrating microstructure-based mechanics, ion-based electrophysiology, and medical imaging. Key objectives include characterizing the stomach's layered structure and distinct...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This $643,049 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a physiomimetic tissue engineering model to investigate the initiation and progression of endometriosis lesions. The research program aims to uncover how the ovarian microenvironment and vascular signals influence the adhesion and invasion of endometriotic epithelial and...
This $599,822 federal Project Grant award was provided by the National Science Foundation's Engineering program (CFDA 47.041) to Northern Arizona University (NAU). The objective of this 3-year project is to use fracture mechanics to study the risk of further tearing in the perineum after an episiotomy, a surgical incision made to widen the vaginal opening during childbirth. The research tasks include developing material models for pelvic floor tissues, evaluating crack-tip stresses from...
This $595,934 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will allow Washington State University to develop advanced musculoskeletal models and simulation approaches to investigate the impact of pregnancy on the musculoskeletal system. The research objectives are to: (i) determine how pregnancy and postpartum alter torso and hip muscle mechanical properties, (ii) assess how spine extensors accommodate changes in muscle mechanics and posture during...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell...