Project Grant 2525949
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $796,823 to the University of Missouri System to conduct research on the genetic and molecular mechanisms behind meiotic silencing by unpaired DNA. The research aims to better understand how organisms use RNA-based gene silencing systems to identify and suppress the expression of DNA segments lacking a pairing partner, which can indicate the presence of viruses or...
- This $1,228,250 National Science Foundation project grant supports research into the B chromosome of maize and its impact on genomic processes. Led by the University of Missouri System, the three-year award aims to advance understanding of properties that have allowed the extra, non-essential B chromosome to persist in maize for millions of years despite providing no benefit to the plant. The interdisciplinary team will conduct genetic and molecular analysis to learn the nature of properties...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $350,000 to the University of Iowa to support research on the mechanisms involved in the propagation of chromosome fragments in the germline. The 3-year project aims to investigate how DNA breaks that occur during the formation of egg and sperm cells are stabilized and passed on to the next generation. The research will be conducted using the model organism C. elegans and will...
- This three-year, $1.8 million project grant from the National Science Foundation Division of Integrative Organismal Systems aims to develop rapid transformation and gene editing techniques in maize through the Biological Sciences program (CFDA 47.074). The University of Missouri System will work to establish a system for precisely inserting transgenes and editing genes at predetermined sites in the genome of maize. Researchers will create "landing pads" on five chromosomes of a...
- This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $656,273 to the University of Montana to conduct collaborative research on the mechanisms and consequences of centromere drive in monkeyflowers. The project aims to investigate how genes and DNA sequences cause selfish centromere drive, how plants resist this drive, and the impacts on seed and pollen production. The research team will leverage new chromosome-scale genome...
- This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...
- This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
- This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
- This $1,691,891 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research by the University of California, Irvine into genome evolution and structure in corn (maize). The project aims to investigate how plant genomes can vary substantially in size and organization, yet still produce functional organisms. Specifically, the researchers will measure and compare the folding structures of 25 corn genomes and two related...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $471,311 to the University of Missouri System to analyze Barbara McClintock's discovery of a "tiny fragment" chromosome and its "X component" that can rapidly reorganize the genome. The key products and services to be delivered include: Digitizing historical microscope slides of chromosomal aberrations and producing an instructional video on whole chromosome painting techniques in maize to be uploaded to the lab's YouTube channel. Conducting experiments to test the hypothesis that changes in transmission frequency of the tiny fragment chromosome are due to genomic rearrangements catalyzed by the X component, and defining their structure using whole chromosome paints and DNA sequencing. Assessing the silencing versus activity of genes on the tiny fragment chromosome through RNA sequencing experiments comparing mRNA to genomic DNA using droplet digital PCR. The award period runs from September 1, 2025 to August 31, 2028, with the goal of advancing scientific understanding of this novel genomic activity that can impact chromosomal changes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $471.3k | 7/29/25 |