Project Grant 2214243
- This three-year, $1.8 million project grant from the National Science Foundation Division of Integrative Organismal Systems aims to develop rapid transformation and gene editing techniques in maize through the Biological Sciences program (CFDA 47.074). The University of Missouri System will work to establish a system for precisely inserting transgenes and editing genes at predetermined sites in the genome of maize. Researchers will create "landing pads" on five chromosomes of a...
- Federal Project Grant Award Summary The University of Missouri System received a $471,311 Project Grant award, effective September 1, 2025 through August 31, 2028, from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The award supports fundamental research analyzing Barbara McClintock's discovery of the "tiny fragment" chromosome and its "X component," which catalyzes dramatic genomic...
- The University of Missouri System received a $400,000 Project Grant from the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective September 1, 2025 through August 31, 2027. This research initiative focuses on elucidating the genetic and molecular basis of heterosis (hybrid vigor) through investigation of the Genomic Balance Hypothesis. The project will test whether increased and more balanced gene expression in...
- This $1,691,891 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research by the University of California, Irvine into genome evolution and structure in corn (maize). The project aims to investigate how plant genomes can vary substantially in size and organization, yet still produce functional organisms. Specifically, the researchers will measure and compare the folding structures of 25 corn genomes and two related...
- This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
- This $3.2 million project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program (CFDA 47.074) supports research at Cornell University to elucidate the meiotic recombination landscape in maize and develop the ability to modify it. The goals are to examine how chromatin, DNA sequence, and genetic diversity impact recombination hotspots; understand how recombination landscapes evolve; and test methods to create artificial hotspots. A...
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $796,823 to the University of Missouri System to conduct research on the genetic and molecular mechanisms behind meiotic silencing by unpaired DNA. The research aims to better understand how organisms use RNA-based gene silencing systems to identify and suppress the expression of DNA segments lacking a pairing partner, which can indicate the presence of viruses or...
- This $418,138 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports collaborative research on the mechanisms and consequences of centromere drive in the yellow monkeyflower plant. The primary awardee is Scripps College, a private liberal arts college in Claremont, CA. The research aims to increase understanding of how centromeres, which guide chromosomes during cell division, can selfishly gain unfair access to egg cells, disrupting fair...
- This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
- This $735,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support research at Cornell University to investigate the interactions of plant transcription factors that regulate the three-dimensional patterning of grass leaves. The research aims to gain a better understanding of the functional interactions between the LIG1 and WOX3 transcription factor genes, which are critical for determining leaf width, length, and angle in grasses like...
This $1,228,250 National Science Foundation project grant supports research into the B chromosome of maize and its impact on genomic processes. Led by the University of Missouri System, the three-year award aims to advance understanding of properties that have allowed the extra, non-essential B chromosome to persist in maize for millions of years despite providing no benefit to the plant. The interdisciplinary team will conduct genetic and molecular analysis to learn the nature of properties that ensure the B chromosome's proper segregation during male meiosis and reproduction, while also studying how its presence has restructured the maize genome over time. Experiments will examine mechanisms like centromere behavior during cell division and the identity of factors involved in nondisjunction. Broader goals include gaining new insight into concepts of genetic drive and genomic conflict. Training will be provided across biological disciplines and involve computational analyses at all educational levels.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 5/19/22 |