Project Grant 2525726
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
- This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
- This $985,496 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by the University of Rochester to develop an innovative platform for controlling and stabilizing microbial communities. The project aims to leverage horizontal gene transfer, specifically through plasmid conjugation, to dynamically balance growth rates and community composition, creating programmable microbial populations capable of maintaining stability across...
- The National Science Foundation Division of Integrative Organismal Systems awarded $550,000 to the Massachusetts Institute of Technology under the Biological Sciences (CFDA 47.074) federal grant program to support the project "EDGE FGT: Genetic Tools for Prochlorococcus That Dominate the Oceans" from May 1, 2021 to April 30, 2023. The project aims to develop genetic tools to study Prochlorococcus, a genus of photosynthetic bacteria that are abundant in oceans worldwide. A sub-award...
- This federal Project Grant award from the National Science Foundation (CFDA 47.074 Biological Sciences) provides $1,271,828 to Northeastern University and its sub-awardees, Tufts University School of Medicine and Tulane University, to develop new approaches for genetically engineering diverse strains of Clostridia bacteria. The research aims to overcome key limitations in Clostridial genetic manipulation, enabling accelerated study and control of their unique physiology and metabolism. The...
- This Project Grant award from the National Science Foundation Division of Integrative Organismal Systems provides $1.6 million to support research under the Biological Sciences program (CFDA 47.074) from August 2021 through July 2024. The grant funds the development of new molecular genetic tools by the J. Craig Venter Institute to define phenotypes in the diatom Pseudo-nitzschia, which can cause harmful algal blooms. Two subawards totaling $100,000 each were provided to the University of...
- This Project Grant award of $968,613 from the National Science Foundation Division of Molecular and Cellular Biosciences supports research into developing a novel CRISPR synthetic biology tool for investigating and reprogramming alkaloid biosynthesis regulation in Catharanthus roseus. The award was made on March 1, 2021 to Northeastern University for work to be completed by December 31, 2024 under the Biological Sciences program (CFDA 47.074). A sub-award of $100,000 was also provided to...
- This Project Grant award from the National Science Foundation (CFDA 47.074 Biological Sciences program) provides $325,751 to Williams College to identify, characterize, and engineer plasmid-encoded modulators of natural plasmid transformation in the bacterium Vibrio natriegens. The research will examine how plasmid sequence parameters such as size, genetic cargo, and replication origins impact the efficiency of plasmid natural transformation - the process by which bacteria take up DNA from their...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
- This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) is focused on developing advanced tools for genetic manipulation of marine bacteria called Vibrios. The $427,981 award to Trustees of Indiana University will fund the creation of tools to enable precise control over protein production from bacterial genes, including methods to turn genes "up" or "down" on a broad scale. This technology aims to expand the biotechnological reach of Vibrio bacteria, which have important applications in food production, disease, and basic microbiology research. The project will make these tools and resulting bacterial strains readily available to the research community, and integrate them into teaching curricula to facilitate broad adoption. This work seeks to advance CRISPR-based approaches for functional genomics in bacteria, providing a valuable platform for a range of biotechnology applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $428.0k | 7/24/25 |