Project Grant 2523475
- The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $250,120 Project Grant to Clemson University to conduct collaborative research on the effect of cellular deformation on the proliferation and motility of single cells. The goal is to engineer specialized microfluidic devices to study how physical stresses experienced by cells in the human body, such as when they move and squeeze through tight spaces, impact their ability to divide and migrate. This research aims to...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This $199,982 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) funds research at Wesleyan University to investigate the principles governing the interactions at the interface between different groups of cells. The project aims to understand how cells from different tissues interact and organize themselves when they come into contact, which is crucial for advancing knowledge in areas such as tissue development, wound healing, and cancer...
- This $400,000 Project Grant, awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), is funding a collaborative research project at the University of Michigan to study the mechanics of tissue boundary formation. The research aims to explain how mechanical forces inside the body help shape developing tissues during early stages of life, by investigating how cells move, interact, and respond to mechanical cues during tissue formation. The 3-year project will combine...
- The National Science Foundation (NSF) is awarding a $360,000 Project Grant under the Engineering program (CFDA 47.041) to the University of Alabama. The grant, with a period of performance from September 1, 2025 to August 31, 2028, will support the development of a 3D engineered model that incorporates innate immune cells (macrophages and microglia) to study drug resistance in brain metastatic breast cancer (BMBC). This biomimetic model will be used to investigate how microglia and macrophages...
- This National Science Foundation Project Grant of $492,743 will fund research into the impacts of intracellular and extracellular hydraulic environments on mammalian cell migration in confined spaces. Awarded on October 15, 2022 under the Engineering program (CFDA 47.041), the funding will support mathematical modeling to decipher the coupled effects of fluid interaction with cellular structures on cell behavior in confined migration. The awardee, the Research Foundation for the State University...
- The National Science Foundation awarded a $396,319 Project Grant to the University of Utah's Office of Sponsored Projects under the Engineering federal grant program (CFDA 47.041). The three-year award will support research into the regulation of cell adhesions by mechanical force from April 2021 through March 2024. As part of its mission to improve engineering research and education, the Engineering program seeks to advance understanding of fundamental engineering principles at the cellular and...
- The National Science Foundation (NSF) Engineering program awarded a $377,755 Project Grant to the University of New Haven, Incorporated to support fundamental research on the mechanoregulation of collective cell migration in biomimetic microenvironments. This 3-year grant, effective from September 1, 2024 to August 31, 2027, will enable the University of New Haven to investigate how mechanical forces and biochemical factors interact to regulate collective cell migration, a crucial process in...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell...
- This National Science Foundation Project Grant of $419,750 will fund research at Washington University in St. Louis from August 1, 2022 to July 31, 2025 to study how living cells move across dissimilar physical environments and retain mechanical memories of prior environments. Specifically, the award will integrate experiments and computational modeling to examine how forces generated by cells modify their surroundings in two mechanically different environments during migration. This will reveal...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $240,146 to the University of Alabama to conduct collaborative research on the effects of cellular deformation on the proliferation and motility of single cells. The research aims to engineer specialized microfluidic devices that simulate the tight spaces cells encounter in the human body, enabling the observation of how physical stress impacts cell division, movement, and "memory" of past stressful experiences. This work could lead to new insights on wound healing, cancer metastasis, and stem cell behavior. The project is expected to be completed by July 31, 2028 and includes efforts to inspire and prepare the next generation of scientists through outreach to middle schools, high school research opportunities, and international experiences for undergraduate students.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $240.1k | 8/1/25 |