The National Science Foundation (NSF) awarded a $1,199,950 Project Grant under the Integrative Activities (CFDA 47.083) program to Arizona State University to design and develop magnetic topological insulators using atomically-precise DNA self-assembly. This convergent research project aims to leverage the unique capabilities of DNA nanostructures to precisely control the electronic and magnetic properties of materials with the goal of realizing novel quantum phenomena for potential applications...
The National Science Foundation (NSF) awarded the University of New Mexico (UNM) a $500,000 Project Grant under the Computer and Information Science and Engineering (CFDA 47.070) program. The grant supports research on the design of heterochiral DNA nanostructures for biomaterials applications. The project aims to study the structure and function of these hybrid DNA materials that combine right-handed (D-DNA) and left-handed (L-DNA) forms, and to use computational modeling and experimental...
The National Science Foundation awarded North Carolina State University $525,836 under the Mathematical and Physical Sciences program (CFDA 47.049) for a three-year project grant completing July 2025. The university will research self-organizing nucleic acid supramolecular assemblies with stimuli-responsive properties. Specifically, the project aims to develop a toolkit for constructing responsive nanoparticle-based materials using rationally designed RNAs as modular building blocks. Researchers...
The University of California, San Diego will deliver a project titled "Responsive Materials from Self-Assembling Nucleic Acid Nanoshapes" through a $535,012 Project Grant from the National Science Foundation under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year award running from July 2021 to June 2024 will support research into developing responsive materials using self-assembling nucleic acid nanostructures. The Mathematical and Physical Sciences...
The National Science Foundation (NSF) awarded a $419,934 CAREER grant titled "HIGH-THROUGHPUT MULTI-AXIAL TENSION-INDUCING DNA ORIGAMI DEVICE FOR INVESTIGATING MECHANOSENSITIVE SIGNALING PATHWAYS AND PROTEIN STRUCTURES UNDER DEFINED TENSION" to Arizona State University's Division (doing business as Orspa) on February 1, 2024. The 5-year project will develop a novel "MAESTRO" device that leverages DNA origami to apply controlled mechanical tension to individual integrin...
The National Science Foundation awarded Northwestern University a $525,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to develop protein crystallization programmed with DNA. This three-year award beginning June 1, 2021 will support research to promote progress in the mathematical and physical sciences by increasing understanding of major problems through the development of new techniques to crystallize proteins using DNA programming. The University will...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
The Ohio State University was awarded a $200,000 Project Grant from the National Science Foundation's Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049). The award supports fundamental research to develop self-assembled materials constructed from DNA with adaptable structures, unique mechanical properties, signal processing capabilities, and the ability to form a variety of materials from a single reconfigurable building block. The research aims...
This $100,000 two-year Project Grant from the National Science Foundation's Office of Emerging Frontiers and Multidisciplinary Activities, under the Engineering (47.041) program, will support research at Boise State University to develop a co-design model integrating DNA nanotechnology and two-dimensional materials for advanced semiconductor manufacturing and workforce development. Specifically, the University will design DNA nanostructure templates for atomic precision patterning and doping...
The National Science Foundation (NSF) Engineering program (CFDA 47.041) has awarded Iowa State University of Science and Technology (Iowa State University) $552,075 for a project titled "Designing DNA Origami for Force-Mediated Release of Molecular Cargo". The project aims to design, build, and test a nanosized container made using DNA origami techniques that can release molecular cargo in response to small forces exerted within tissues. Key tasks include selecting extracellular matrix...
The National Science Foundation (NSF) Division of Materials Research awarded a $499,999 Project Grant to Arizona State University (ASU) under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year grant project aims to: 1) create 3D DNA crystal scaffolds to host and determine the structure of RNA aptamers; 2) attach and immobilize functional proteins like enzymes within the crystal lattices to develop catalytic materials; and 3) develop sub-100 nm DNA nano-crystals to effectively deliver small interfering RNA (siRNA) or proteins into cells. The project will also develop educational curriculum and outreach activities to promote nanotechnology and STEM fields. By leveraging the programmable and modular properties of DNA self-assembly, the funded research seeks to advance fundamental understanding and engineering of nucleic acid-based functional materials.