Project Grant 2515448
- The Pennsylvania State University received a $271,247 Project Grant award from the National Science Foundation Division of Materials Research on July 1, 2021 to support research titled "Probing Microbe-Material Interactions towards In Situ Gut Microbiome Engineering." The award is being used to fund research through December 31, 2022 exploring interactions between microbes and materials to advance in situ engineering of the gut microbiome. The research is aligned with the...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $719,638 to Cornell University to conduct fundamental research on the nanomechanics of bacterial adhesion and growth on healthy and diseased human gut mucus. The research aims to determine how differences in the molecular structures of healthy and diseased gut mucus impact bacterial adhesion and biofilm formation. The project will use computational modeling and simulations to obtain...
- This federal Project Grant award of $914,479 from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund a research project led by The Trustees of Columbia University in the City of New York to study the spatial organization and stability of synthetic gut microbiome communities in gnotobiotic mice. The research aims to elucidate the principles governing the assembly and persistence of microbial communities in the human digestive tract, which are essential for human...
- This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides USD 270,000 in funding from August 1, 2025 to July 31, 2028. The award supports a Postdoctoral Research Fellowship focused on deciphering the role of pyrazine biosynthetic enzymes in host-colonization dynamics and gut chemical diversity within the gut microbiome. The research aims to increase understanding of how microbial communication influences colonization of the host gut...
- This Project Grant award, valued at $502,674, was provided by the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program to Minnesota State University Mankato. The funding will support a research project investigating the role of nitrogen source availability in shaping the composition and function of gut microbiomes across different mammalian host species. Key project activities include computationally reconstructing microbial nitrogen transformation networks...
- This Project Grant award of $1,066,082 from the National Science Foundation's Biological Sciences (CFDA 47.074) program will support research to enhance the understanding of mechanisms that allow beneficial bacteria to successfully colonize plants and exclude pathogens. The project will use synthetic microbial communities and advanced genetic and genomic approaches to identify the molecular, ecological, genetic, and genomic factors that facilitate or prevent microbial community invasion. The...
- This $499,996 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) will fund a research project conducted by The Pennsylvania State University to reconstruct the history of the human oral microbiome on a global scale. The project aims to understand the evolutionary mechanisms that drive changes in human microbiome diversity over time, particularly in response to shifts in geography, environment, and culture. By analyzing bacteria...
- This $552,957 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to develop an in-vitro microfluidic platform to study the interaction between gut microbiota and brain tissue models, particularly in the context of neurodegenerative disorders. The project, awarded to Iowa State University of Science and Technology, will integrate research and education to train undergraduate and graduate students in interdisciplinary studies of the...
- This federal Project Grant award of $100,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will support collaborative research to better understand bacterial locomotion through complex biological fluids like mucus. The research will combine mathematical modeling, computer simulations, and laboratory experiments to investigate how bacteria, using their flagella, propel themselves through viscoelastic fluids. The project aims to develop a...
This Project Grant award from the National Science Foundation (NSF) under the Engineering Program (CFDA 47.041) provides $450,000.00 to The Pennsylvania State University (Penn State) to investigate the role of gut microorganisms in controlling human health, with a focus on microorganism interactions with the gut sugar polymer mucin. The project aims to use miniaturized models of synthetic gut bacterial communities to explore gut modifications by both beneficial and pathogenic bacteria, including investigating the uncharacterized role of invasive, pathogenic Escherichia coli strains in distributing mucin. This work will enhance the understanding of how human health depends on a healthy gut microbial community and identify methods to correct gut communities causing disease. The project period runs from September 1, 2025 through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $450.0k | 8/18/25 |