Project Grant 2514394
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal project grant award provides $1,100,000 to the University of Massachusetts Medical School (UMMS) to systematically investigate a novel bacterial DNA-targeting immune system known as DDMDE. The project aims to transform genome editing capabilities by revealing how DDMDE identifies target DNA sequences and recruits partner enzymes to cut unwanted DNA, without relying on the genetic signatures required by CRISPR....
- The National Science Foundation (NSF) has awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of Delaware. The objective of this 3-year grant, which runs from August 2024 to July 2027, is to develop a new strategy for real-time metabolite sensing and metabolon formation using biomolecular condensates. The research aims to create synthetic ligand-responsive transcription factor-based protein devices that can translate metabolite-induced DNA...
- The National Science Foundation (NSF) is awarding a $360,000 Project Grant under the Engineering program (CFDA 47.041) to the University of Alabama. The grant, with a period of performance from September 1, 2025 to August 31, 2028, will support the development of a 3D engineered model that incorporates innate immune cells (macrophages and microglia) to study drug resistance in brain metastatic breast cancer (BMBC). This biomimetic model will be used to investigate how microglia and macrophages...
- This federal Project Grant award of $430,675.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the University of Delaware's research project titled "Probing Spatiotemporal Mechanobiology Through Novel Dynamic Material Platforms." The project, awarded on September 15, 2025, with an ultimate completion date of August 31, 2030, aims to develop innovative engineered materials...
- This Project Grant award of $621,158 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program, supports research to create a "human macrophage design toolkit" for engineering therapeutic macrophages. The goal is to elucidate the biological and gene circuit design principles needed to engineer macrophages that can suppress inflammatory...
- This Project Grant award of $550,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Iowa State University to investigate how different histone writer enzymes coordinate to regulate gene expression and chromatin structure. The project will explore how the histone modifications H3K9me2, H3S10ph, and H4K16ac work together to fine-tune gene expression levels by controlling chromatin accessibility. Experiments will utilize Drosophila larval...
- This Project Grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), provides $900,000 in funding to The Regents of the University of Colorado from February 1, 2025 to January 31, 2028. The project focuses on uncovering the molecular mechanisms by which the DNA methyltransferase 1 (DNMT1) enzyme regulates gene silencing and the inheritance of distinct cell identities. The research will utilize structural biology, biochemistry, and cell biology methods to...
- This $483,492 Project Grant awarded by the National Science Foundation's Engineering program to the University of Maryland, College Park, aims to develop biomaterial tools for investigating how extracellular matrix (ECM) ligands influence the function of macrophage immune cells. The 5-year project will leverage polyethylene glycol-based biomaterials with known peptide-derived ECM ligands to quantify the impact of ECM ligand-integrin receptor interactions on macrophage activation. The research...
- This National Science Foundation Project Grant of $676,969 supports research at North Dakota State University from May 1, 2023 to April 30, 2028 under the Engineering program (CFDA 47.041). The grant aims to advance fundamental understanding of enzyme interactions with stimuli-responsive nanoparticles at the nanoscale. Specifically, the Principal Investigator will develop histone-mimetic polymerosomes capable of selectively recognizing target enzymes like histone deacetylase, and study how their...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
This $300,000 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research by the University of Delaware to decipher and manipulate the role of histone lactylation in controlling macrophage immune cell behavior. The project aims to create precision synthetic biology tools that can add or remove lactylation marks on DNA-packaging proteins, enabling a better understanding of how lactylation affects macrophage polarization between inflammatory (M1) and anti-inflammatory (M2) phenotypes. This research could lead to new ways to control immune responses in diseases like cancer. The project will also develop course modules and support undergraduate researchers to help grow the biomanufacturing workforce. The award period runs from September 1, 2025, to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 8/5/25 |