Project Grant 2514152
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This $380,785 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Cornell University. The grant supports research to develop new algorithms for quantitatively recovering protein conformational ensembles from cryogenic electron microscopy (cryo-EM) data. The key objectives are to accelerate computational methods for matching simulated and experimental cryo-EM images, and to utilize...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $980,943 to Purdue University from August 1, 2025 to July 31, 2029. The project aims to develop new artificial intelligence (AI) tools that can automatically interpret cryogenic electron microscopy (cryo-EM) data into accurate 3D molecular structures and validate those structures for errors. The key objectives are: (1) developing deep learning methods to...
- The National Institutes of Health (NIH) awarded a $1,476,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Trustees of Princeton University for a project titled "Algorithms and Software for Biomolecular Structure Determination at the Proteome Scale". The objective of this 3-year project, starting on September 9, 2025 and ending on August 31, 2028, is to develop novel artificial intelligence (AI) and machine learning (ML) methods to address critical...
- The National Science Foundation (NSF) Division of Chemistry awarded a $1,500,000 Project Grant to Stanford University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The grant, awarded on March 1, 2024, supports a 3-year research project titled "Evaluating and Advancing Cryo-EM for RNA Conformational Ensembles." The project aims to: (1) design, model, and experimentally probe RNA systems with discrete conformational states, and (2) characterize and challenge...
- This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program, CFDA 47.070, provides $174,984 to Georgia Southern University Research & Service Foundation Inc. to develop a novel artificial intelligence (AI)-based computational framework. This framework aims to enhance the accuracy of modeling protein structures from medium-resolution cryo-electron microscopy (cryo-EM) images. By combining static quality information with...
- This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences program (CFDA 47.049), provides $300,000 in funding to Princeton University to develop novel computational methods for recovering signals from highly corrupted and distorted data. The key products to be delivered include: New algorithms and mathematical foundations to enable effective extraction and analysis of information from data collected by advanced imaging technologies, such as...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded The Trustees of Columbia University in the City of New York a $1,200,000 Project Grant on March 15, 2025 to develop and apply a method of time-resolved cryo-electron microscopy (cryo-EM) to diverse biological molecules of medical importance. The project aims to use newly designed PDMS-based microfluidic chips to apply the time-resolved cryo-EM sample preparation technique, which has been...
This Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program provides $250,000 to the University of California, Davis to develop fast and robust algorithms for 3D molecular structure reconstruction from cryo-electron microscopy (cryo-EM) data. The project aims to overcome the computational barriers limiting the widespread adoption of cryo-EM by creating new algorithms for image alignment and molecular orientation estimation. These innovations will enable researchers to extract higher-resolution 3D protein structures more quickly and reliably, accelerating scientific discoveries in biomedicine and supporting drug development. The project will also include graduate student training. The new algorithms will be implemented as open-source software to broadly benefit applications in biomedical imaging, computer vision, and robotics. The grant is active from September 1, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $250.0k | 7/17/25 |