This Project Grant award, provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) program, supports research on a new class of materials called protein-like polymers (PLPs). The $170,954 award funds a collaborative research effort to study how these PLP materials can mimic the structure and function of proteins, enabling them to interact with and penetrate biological membranes and cells. The goal is to elucidate the mechanisms by which...
This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
The University of California, San Diego will deliver a project titled "Responsive Materials from Self-Assembling Nucleic Acid Nanoshapes" through a $535,012 Project Grant from the National Science Foundation under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year award running from July 2021 to June 2024 will support research into developing responsive materials using self-assembling nucleic acid nanostructures. The Mathematical and Physical Sciences...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $273,291 to the University of California, Santa Barbara to develop computational tools that combine machine learning and scientific computing for the exploration and prediction of polymer systems. The goal is to accelerate the discovery of new materials and provide a framework for computationally costly problems across various scientific domains. The research...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $405,431 to The Regents of the University of California, doing business as University of California, Berkeley, to conduct collaborative research on developing polymers with adaptive molecular structures that can withstand extreme conditions. The key objectives are to: 1) pioneer the use of double-threaded polymers to fabricate slide-ring polymers for enhanced...
This $3 million National Science Foundation project grant supports research at the University of Texas at Austin to develop synthetic adhesive cells for controlled intracellular delivery. Funded under the Biological Sciences program (CFDA 47.074), the three-year award will engineer synthetic cells with user-defined control over molecular transfer between synthetic and live cells. Researchers will build on prior work developing synthetic cells that form adhesive junctions and transfer cargo...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $586,230 to The Leland Stanford Junior University to conduct research on the physical organization and molecular transport mechanisms of the cell membrane glycocalyx. The project aims to develop a fundamental biophysical understanding of how the proteins and sugars that make up the protective "shield" on cell surfaces modulate the interactions of proteins, polysaccharides,...
This National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences project grant for $300,000 aims to engineer shape-morphing materials as cell sheet culturing substrates to develop human tissues with controllable shape, cellular composition, and morphology. The 3-year project, beginning on September 1, 2023, will use thermoresponsive hydrogels to enable cell sheet expulsion and explore how material characteristics impact stem cell fate. Additionally, the project seeks...
This $495,000 Project Grant from the National Science Foundation's Division of Chemistry and Mathematical and Physical Sciences program will fund research at the University of California, San Diego to develop electrochemical and photochemical methods for precision synthesis of conjugated polymers. Led by Nathan Romero, the three-year project beginning July 2023 aims to achieve length- and sequence-controlled polymerization of conjugated polymers using a combination of electrochemical and...
This Project Grant award, funded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), supports research at the University of Utah to develop chemically tunable models of the cellular glycocalyx - the sugar and protein coating on cell surfaces. Led by Professor Jessica Kramer, the $543,251 project from September 2024 through August 2027 aims to create synthetic mucin glycoproteins to engineer the...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program, CFDA 47.049, provides $418,280 to the University of California, San Diego to develop new methods for attaching synthetic polymers to the surface of cells. The goal is to enable precise control over how cells interact with their external environment, which is important for advancing cell-based technologies like cell-based therapeutics, biosynthesis, and sensors. The project will focus on using ring-opening metathesis polymerization to create these cell-polymer hybrid materials, and will develop techniques for labeling cell surfaces as well as evaluate the long-term effects on cell health and function. The project is expected to run from August 1, 2025 to July 31, 2028 and will also provide research opportunities for undergraduate transfer students to improve their academic and career outcomes.