Project Grant 2506192
- The National Science Foundation (NSF) awarded a $550,000 Project Grant to Colorado State University (CSU) under the CFDA 47.049 Mathematical and Physical Sciences program. The grant supports CSU's Dr. Margarita Herrera-Alonso in exploring the formation of gene-carrying nanoparticles from synthetic macromolecules with complex architectures. The goal is to establish design principles for polymer/gene assemblies that can enhance the stability and therapeutic efficacy of gene therapy delivery...
- The National Science Foundation (NSF) awarded a $600,000 project grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Research Foundation of the City University of New York (RFCUNY) to support Professor Mahesh Lakshman's research on developing novel chemical methods for modifying nucleosides. Nucleosides are the fundamental building blocks of DNA and RNA, and this research aims to obtain a better understanding of chemical processes to enable selective modifications...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $364,550 to Amherst College to study the rules for designing active DNA materials using condensing agents. The key objectives are to investigate how condensing agents can bend, loop, and reconfigure DNA in order to impart desirable properties like decreased size, increased stability, and altered electrical conductivity. The research will be conducted entirely by...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), has awarded a $749,999 Project Grant to Princeton University and San Diego State University. The grant will fund the development of a novel method for tracking the synthesis, localization, and dynamics of RNA messages in living cells using metabolically incorporated fluorescent nucleosides. This innovative approach will enable researchers to study the organization of cellular structures...
- This $605,020 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research conducted by Professor Byron Purse of the Department of Chemistry and Biochemistry at San Diego State University. The research aims to determine how molecular structure and local environment influence key properties of fluorescent nucleobase analogues (FBAs), which are synthetic molecules that mimic natural genetic bases and enable sensitive...
- This Project Grant, awarded by the National Science Foundation's Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), provides $583,025 to Professors Shiyue Fang and Yinan Yuan of Michigan Technological University to develop new chemical technologies for the synthesis of long oligonucleotides (DNA and RNA segments). The research aims to overcome limitations of current biological methods and enable cost-effective production of long oligonucleotides essential for applications in...
- This National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences (CFDA 47.049) program provides funding of $151,584 to The University Corporation at California State University, Northridge to support collaborative research on developing new ligands for the synthesis of noble metal nanocrystals with controlled surface structures. The project aims to expand the synthetic toolbox for nanocrystal chemistry by incorporating designed N-heterocyclic carbenes as...
- This Project Grant award of $300,000 from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for simulation-guided design of DNA nanostructures and molecular systems. The project aims to integrate high-level and low-level computational models to enable more powerful and user-friendly multiscale modeling frameworks for DNA nanotechnology. Key objectives include parameterizing coarse-grained...
- This Project Grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), provides $900,000 in funding to The Regents of the University of Colorado from February 1, 2025 to January 31, 2028. The project focuses on uncovering the molecular mechanisms by which the DNA methyltransferase 1 (DNMT1) enzyme regulates gene silencing and the inheritance of distinct cell identities. The research will utilize structural biology, biochemistry, and cell biology methods to...
- This $575,000 Project Grant award from the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Berkeley will support Professor Thomas Maimone's research on developing new synthetic strategies for constructing complex, nitrogen-containing molecules. The work aims to identify transformations that can efficiently produce unique target molecules with potential applications in pharmaceuticals, agrochemicals, and materials. The...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $345,248 to California State University, Northridge (CSUN) to design and synthesize hybrid molecules containing carbamate nucleic acids (CNAs) coupled with triphenylmethane dyes and dimerization moieties. The objective is to create CNA-based compounds that can bind to the DNA major groove and potentially regulate gene expression as novel small-molecule therapeutics. This research project trains undergraduate and master's-level graduate students at CSUN in organic synthesis, biophysical, and biochemical techniques to assess the ability of these synthetic molecules to affect gene regulation. An outreach program is also included to introduce local high school students to STEM research. The award period runs from September 1, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $345.2k | 8/15/25 |