Project Grant 2506139
- The National Science Foundation (NSF) awarded a $150,620 CAREER Project Grant to the Colorado School of Mines under the Mathematical and Physical Sciences program (CFDA 47.049) to conduct research on polymer-mediated delivery of genome-editing proteins. The goal is to develop innovative methods to efficiently test different polymer designs and quickly identify the best polymer-protein combinations for delivering genome-editing proteins to various cell types, with the aim of advancing...
- Colorado State University was awarded a $540,000 project grant from the National Science Foundation Division of Physics under the Mathematical and Physical Sciences program (CFDA 47.049) for the period of September 15, 2021 through August 31, 2024. The grant funds research into post-transcriptional regulation of gene expression from molecular interactions to the network level. The Mathematical and Physical Sciences program aims to advance scientific knowledge and understanding in these fields...
- The National Science Foundation (NSF) awarded a 5-year, $695,000 Project Grant under the Engineering program (CFDA 47.041) to Case Western Reserve University (CWRU). The grant supports research to investigate the structural implications of nucleic acid nanoparticles on their transcription, translation, and transport for delivering therapeutic drug molecules or genes to cells. Key objectives include: Encoding synthetic DNA nanoparticles with gene sequences and measuring their interaction with the...
- The National Science Foundation awarded North Carolina State University $525,836 under the Mathematical and Physical Sciences program (CFDA 47.049) for a three-year project grant completing July 2025. The university will research self-organizing nucleic acid supramolecular assemblies with stimuli-responsive properties. Specifically, the project aims to develop a toolkit for constructing responsive nanoparticle-based materials using rationally designed RNAs as modular building blocks. Researchers...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $364,550 to Amherst College to study the rules for designing active DNA materials using condensing agents. The key objectives are to investigate how condensing agents can bend, loop, and reconfigure DNA in order to impart desirable properties like decreased size, increased stability, and altered electrical conductivity. The research will be conducted entirely by...
- Colorado State University was awarded a $490,000 Project Grant from the National Science Foundation Division of Chemistry from September 1, 2021 through August 31, 2024. The grant supports research under the Mathematical and Physical Sciences program (CFDA 47.049) to advance understanding of dynamic speciation and complex reaction pathways to inform the rational synthesis of ternary semiconductor nanoparticles. Funding will allow CSU researchers to gain molecular-level insights that can...
- This $500,000 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), supports research to develop a mathematical framework for understanding how porous materials can enhance the efficiency of viral transduction in engineered cell therapies. The award was granted to North Carolina State University (UEI: U3NVH931QJJ3) and will run from September 1, 2025 to August 31, 2028. The key objective of this project is to...
- The National Science Foundation awarded a $568,044 Project Grant to Michigan Technological University from October 1, 2021 to September 30, 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The grant supports collaborative research to predict molecular interactions that can stabilize viral therapies. The Mathematical and Physical Sciences program aims to advance scientific knowledge and enhance understanding of major problems through support of mathematical and physical...
- The National Science Foundation (NSF) Division of Materials Research awarded a $499,999 Project Grant to Arizona State University (ASU) under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year grant project aims to: 1) create 3D DNA crystal scaffolds to host and determine the structure of RNA aptamers; 2) attach and immobilize functional proteins like enzymes within the crystal lattices to develop catalytic materials; and 3) develop sub-100 nm DNA nano-crystals to...
- This National Science Foundation (NSF) Project Grant, awarded under the Mathematical and Physical Sciences (CFDA 47.049) program, provides $233,333 to The Ohio State University to develop and implement multifunctional DNA-based nanoscale devices. The goal is to detect genetic activity and control gene expression, particularly related to cell state and differentiated functions. The devices will enable mechanical control of gene regulation and provide insights into how chromatin structure and...
The National Science Foundation (NSF) awarded a $550,000 Project Grant to Colorado State University (CSU) under the CFDA 47.049 Mathematical and Physical Sciences program. The grant supports CSU's Dr. Margarita Herrera-Alonso in exploring the formation of gene-carrying nanoparticles from synthetic macromolecules with complex architectures. The goal is to establish design principles for polymer/gene assemblies that can enhance the stability and therapeutic efficacy of gene therapy delivery systems. The research aims to advance fundamental understanding of structure-property relationships for these systems, which could enable breakthroughs in treating diseases like cancer, cardiovascular disease, and neurodegenerative conditions through gene therapy. The project will involve disseminating findings through conferences, publications, and educational/outreach efforts targeting students from high school to graduate levels. The award period is from August 1, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $550.0k | 7/25/25 |