This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) project grant award for $595,875 provides funding to the University of Pittsburgh to develop a computational framework for obtaining accurate allele-specific expression measurements and haplotypes from RNA-seq and genotype data. The framework will combine existing methods for transcript expression quantification and haplotype inference into a single, computationally efficient model. Key innovations include a rigorous approach to obtaining identifiable allele-specific expression estimates at various levels, and jointly estimating allele-specific expression and haplotypes that are consistent with each other. The research outcomes will advance various aspects of biological research requiring accurate allele-specific expression and haplotype data, including mapping allele-specific eQTLs, detecting imprinted genes, and detecting recombination events. The award term is from October 1, 2024 to August 31, 2025.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $595.9k | 11/13/24 |