Project Grant 2504115
- The Project Grant award, titled "Identification of Host-Encoded RNA Binding Proteins that Promote P-Element Transposition," is funded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074). The project aims to identify host cellular proteins that regulate transposable elements (TEs), which are mobile genetic fragments that can cause DNA damage and harmful mutations in the host genome. The research will utilize new approaches to study the regulation of TE...
- This $900,000 federal Project Grant award was provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to The Johns Hopkins University. The grant will support research to investigate the mechanistic roles of hyper-divergent regions in gene-by-environment interactions and their impact on adaptation. The project will use cutting-edge genomics, genetic crosses, and high-throughput experiments with nematode species to uncover molecular details on how evolution...
- This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program has awarded a $279,000 Postdoctoral Fellowship Project Grant to Dr. Galen Martin at Purdue University. The 3-year grant, which commenced on Jul 1, 2025, supports a research and training plan titled "Determinants of Evolutionary Success for Active Transposable Element Populations in the Maize Genomic Ecosystem." The project aims to investigate the proliferation of transposable elements, which...
- This $363,800 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by The Johns Hopkins University investigating how supercoiled DNA impacts transcription, a core process of life that converts genetic information into RNA. The research will: Characterize how supercoiling affects transcription kinetics and correlation using in vitro single-molecule imaging of purified proteins and DNA constructs. Determine how chromosomal...
- This Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) provides $179,978.00 to South Dakota State University to conduct research on the mechanistic regulation of dynamic gene expression patterns by temporal JNK activation. The project aims to expand understanding of how cells process information and respond to stress, with a focus on two key mechanisms: post-transcriptional regulation of genes through mRNA stability and combinatorial...
- This Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), will support research to investigate how the three-dimensional organization of the human genome controls gene expression and cell identity in the brain. The $300,000 award, spanning August 2025 to July 2027, will fund the development of new AI-powered tools to reconstruct 3D chromosome structure from single-cell experiments and simulate how changes in genome structure affect...
- This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to develop improved computational methods for human gene annotation. The $387,500 award to The Johns Hopkins University will fund efforts to adapt and expand their existing StringTie software system, a genome-guided transcriptome assembler, to process large-scale RNA sequencing data and build a comprehensive,...
- This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
- This $240,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) funds a postdoctoral research fellowship to investigate the role of genome organization on de novo gene origination. The research aims to test a new theoretical model explaining the process of new gene evolution, by examining how the genome's structural features influence the birth of genes that arise from non-coding regions. The key components of the research include: 1)...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to characterize the contributions of transposable elements, or "jumping genes," to the human transcriptome. The $875,379 project, awarded to The Johns Hopkins University on August 1, 2025, aims to develop a deep learning model that can predict exonization of transposable elements directly from genome sequences, without the need for extensive gene and tissue surveys. The project will use this model to identify Alu exonization events in humans and primates, and compare them to understand the ongoing contributions of Alu insertions to genetic variation. The resulting knowledge, methods, and software tools will help biologists more comprehensively analyze genomes, contribute to public awareness of transposable element plasticity, and provide new insights into the molecular bases of human traits.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $875.4k | 8/14/25 |