Project Grant 2503350
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $465,000.00 to the University of Virginia to conduct research on foldable bottlebrush polymers. The key objectives are to establish relationships between the molecular architecture, mesoscopic conformation, and macroscopic properties of these foldable bottlebrush polymers, as well as to demonstrate their application as a new class of resins for multi-material additive...
- The National Science Foundation Division of Chemistry awarded Northeastern University a $500,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support the de novo asymmetric synthesis of natural and unnatural oligosaccharide motifs from August 15, 2021 through July 31, 2024. This funding will advance progress in the mathematical and physical sciences by enabling Northeastern University researchers to increase the store of scientific knowledge...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $600,000 to Dr. Jia Niu of Boston College to develop a new class of sugar-based polymers called "pseudo-polysaccharides." The project aims to design affordable and easily produced sugar-based building blocks, then assemble them into polymers with precise control over size and functional groups. These new polymers could lead to more sustainable plastics and...
- This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
- This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Lehigh University, in the amount of $199,999, aims to investigate the use of charged polymer complexes as a novel platform for dual drug delivery. The key objectives are: (1) complexing a charged degradable polymer with an oppositely charged peptide or protein; (2) monitoring the kinetics of the degradable polymer breakdown both as part of the complex and free in solution; and (3) incorporating a third...
- This Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences Program (CFDA 47.049) provides $250,000 to support the synthesis of innovative polymeric materials using biologically inspired nanoparticles called "bundlemers". Professors Christopher J. Kloxin and Darrin J. Pochan at the University of Delaware will leverage the unique features of bundlemers to precisely position molecular species and enable the creation of new complex...
- The National Science Foundation (NSF) awarded a $150,620 CAREER Project Grant to the Colorado School of Mines under the Mathematical and Physical Sciences program (CFDA 47.049) to conduct research on polymer-mediated delivery of genome-editing proteins. The goal is to develop innovative methods to efficiently test different polymer designs and quickly identify the best polymer-protein combinations for delivering genome-editing proteins to various cell types, with the aim of advancing...
- This $566,820 National Science Foundation Project Grant, funded through the Mathematical and Physical Sciences program (CFDA 47.049), supports research at the University of Pittsburgh to develop novel brush copolymer materials with two-dimensional sequence control. Professor Tara Meyer will prepare brush copolymers containing biodegradable and biocompatible lactic and glycolic acid side chains of varying sequences. The research will investigate the combined effects of backbone and sidechain...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $364,550 to Amherst College to study the rules for designing active DNA materials using condensing agents. The key objectives are to investigate how condensing agents can bend, loop, and reconfigure DNA in order to impart desirable properties like decreased size, increased stability, and altered electrical conductivity. The research will be conducted entirely by...
- This Project Grant, awarded by the National Science Foundation's Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), provides $583,025 to Professors Shiyue Fang and Yinan Yuan of Michigan Technological University to develop new chemical technologies for the synthesis of long oligonucleotides (DNA and RNA segments). The research aims to overcome limitations of current biological methods and enable cost-effective production of long oligonucleotides essential for applications in...
This federal Project Grant award from the National Science Foundation (CFDA 47.049 - Mathematical and Physical Sciences) provides $620,209 to Northeastern University to develop a platform for rational design of polymer-based oligonucleotide delivery vehicles using digital bottlebrush architectures. The key goals are to: (1) synthesize and characterize a library of ribose-based digital bottlebrush polymers with controlled hydrophobicity and charge, and (2) study their biodistribution, pharmacokinetics, immune response, and therapeutic efficacy in vitro and in vivo. The research integrates synthetic chemistry, biomaterials science, molecular biology, and machine learning to expand oligonucleotide delivery capabilities for genetic medicines. The project has a performance period from August 1, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $620.2k | 7/16/25 |