This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at Duke University to investigate how single-cell phenotypic heterogeneity arises and can be controlled in T cells, which are a key component of the immune system. The $574,808 award, granted on May 1, 2025, aims to link dynamic cellular behaviors to molecular phenotypes using advanced technologies such as spatial proteomic multiplexed imaging, in vitro cell tracking, and...
This $425,486 federal Project Grant award to the University of North Carolina at Chapel Hill (UNC-CH) was made by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program. The project aims to study the evolutionary history and functional diversification of the CD300 gene family, which encodes immune receptors implicated in human health issues like cancer, inflammation, and viral infections. Using a multi-omic approach, the research will map the molecular and...
This Project Grant award, funded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program, supports a collaborative research project to evaluate innate immune responses across vertebrate evolution, with a focus on the CD300 protein family. The $458,015 award to the University of North Carolina at Charlotte aims to map the molecular and functional diversification of CD300 orthologs and paralogs, and experimentally test ancestral CD300 functions. The research...
This National Science Foundation (NSF) Engineering Program Project Grant, awarded to the University of South Florida (USF), aims to gain a fundamental understanding of the parameters of chimeric antigen receptors (CARs) that tune T cell responses, and to characterize how these parameters affect CAR engineered T cell function and fate. The $501,979 award, effective February 1, 2024 through January 31, 2029, will combine protein engineering, cell biology, and omics experiments to survey motif...
The Trustees of the University of Pennsylvania received a $375,708 Project Grant award from the National Science Foundation to support the CAREER: SYSTEMS IMMUNOLOGY APPROACH TO MEMORY T CELL IMMUNE ENGINEERING project. The grant was awarded on June 1, 2021 under the NSF Engineering Program (CFDA 47.041) to fund research from June 2021 through June 2022. The project aims to apply systems immunology approaches to engineer memory T cell immune responses. As part of its mission to improve...
This $508,785 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at Columbia University to investigate how the chemical composition and mechanical properties of biomaterials can be optimized to improve the production and function of T cells for use in cancer immunotherapy. The project aims to gain fundamental knowledge on how nutrient transport, particularly oxygen availability, within these biomaterials affects T cell...
This National Science Foundation Project Grant of $476,137 supports research into the dynamic characteristics of antigen recognition by immune cells at the University of California, Los Angeles from August 1, 2022 through July 31, 2025. The grant is part of NSF's Biological Sciences program (CFDA 47.074), which aims to increase scientific knowledge and understanding of problems in biology through basic research support. Specifically, the grant will fund experimental and computational research to...
This $379,730 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports the development of a continuous electrochemical sensor system for monitoring therapeutic monoclonal antibodies (mAbs), using the FDA-approved mAb bevacizumab as an example. The research aims to create light-sensitive, reversible aptamer sensors that can continuously track mAb concentrations in the body, enabling clinicians to better titrate these therapies for chronic...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $645,180 to North Carolina State University to conduct a collaborative research project titled "OSIB: A Multi-Omic Evaluation of Innate Immune Responses Across Vertebrate Evolution." The research aims to investigate the evolutionary history and functional diversification of the CD300 gene family, which encodes proteins playing crucial roles in immune function and disease...
This National Science Foundation (NSF) Project Grant award under the Social, Behavioral, and Economic Sciences program (CFDA 47.075) provides $250,000 in funding to Old Dominion University Research Foundation (Odurf) from May 1, 2025 to April 30, 2027. The objective of this research is to develop low-cost, Good Manufacturing Practice (GMP)-enabled mRNA-based manufacturing technologies for Chimeric Antigen Receptor (CAR) T-cell therapies. The project will investigate protein expression and...