This Project Grant award, provided by the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083), will support the development and experimental validation of computational tools for designing DNA nanostructures and molecular systems. The $300,000 grant, awarded on February 1, 2025 with a project duration through January 31, 2027, aims to create novel multiscale modeling frameworks that integrate high-level and low-level simulations to predict the behavior of engineered...
The National Science Foundation (NSF) awarded a $1,384,726 Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Arizona State University (ASU) to develop the open-source OxDNA ecosystem for modeling nucleic acid nanotechnology. The project aims to transition the mature OxDNA simulation tools and design software into an open, collaborative ecosystem where academic researchers and the biotechnology industry can contribute towards advancing the complexity of...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,932 to Femtofluidics Incorporated aims to develop hardware that will enable the rapid and inexpensive synthesis of DNA-encoded libraries (DELs). The goal is to expedite drug discovery and generate data to train artificial intelligence (AI) models, strengthening U.S. competitiveness in drug discovery and reinforcing leadership in automation and AI research. The technology will...
The National Science Foundation awarded Diant Pharma Inc. a $256,000 Project Grant under the Engineering (47.041) federal grant program. The grant will support development of an advanced continuous manufacturing system for nucleic acid lipid nanoparticles to improve supply chains for therapeutics and vaccines. Specifically, the small business innovation research Phase I project aims to create a compact, end-to-end manufacturing platform that follows current good manufacturing practices. This...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program award provides $274,990 to Dencoda LLC to develop a novel DNA-based kinase assay platform. The key products to be delivered are: A highly sensitive, specific, and multiplexed kinase activity assay that can be used as a research tool to discover new therapeutic targets or as a clinical diagnostic test for diseases involving kinase dysregulation, such as cancers, diabetes, and Alzheimer's disease....
The National Science Foundation (NSF) awarded the University of New Mexico (UNM) a $500,000 Project Grant under the Computer and Information Science and Engineering (CFDA 47.070) program. The grant supports research on the design of heterochiral DNA nanostructures for biomaterials applications. The project aims to study the structure and function of these hybrid DNA materials that combine right-handed (D-DNA) and left-handed (L-DNA) forms, and to use computational modeling and experimental...
The National Science Foundation (NSF) awarded a $274,438 SBIR Phase I grant to Script Biosciences Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project, titled "CASPLUS: A Safer, More Efficient, and Targeted Method of Deploying CRISPR In Vivo," aims to develop a platform technology that significantly reduces the potential inaccuracy of current gene editing techniques. The innovation targets the desired gene, increasing the safety and efficacy of...
The National Science Foundation (NSF) awarded a $1,250,000 Cooperative Agreement under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to Micropure Genomics Inc., a minority-owned small business located in Middletown, DE. The funding supports the development of an innovative platform for preparing high-quality DNA samples to enable broader adoption of long-read sequencing technologies. Key objectives include fabricating user-friendly cartridges and instruments,...
This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) is providing $275,000 to Dinya DNA Inc. to support the commercial development of a novel DNA synthesis technology. The key products or services being delivered include: Developing new methods to ensure higher fidelity DNA precursors, which are the building blocks for DNA synthesis Reducing synthesis costs by streamlining the DNA synthesis reactions...