This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a new, highly automated, and low-cost method for producing long synthetic DNA molecules. The $295,923 award to Avery Digital Data, Inc. will fund research into using electronic nanochannel chip devices to precisely control the motion of DNA fragments and enable the assembly of longer, gene-length DNA constructs....
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award provides $274,932 to Femtofluidics Incorporated to develop hardware that can rapidly and inexpensively synthesize DNA-encoded libraries (DELs) for drug discovery. The project aims to create an electronic device that can manipulate nanoliter to picoliter volume droplets to perform combinatorial chemistry, overcoming limitations of traditional liquid-handling robots. This technology...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of an autonomous, miniaturized system for DNA extraction and preparation for sequencing. The $275,000 award to Anyglabs, Inc. will fund the creation of a portable, automated device capable of high-throughput DNA processing in space and other austere environments. The goal is to democratize access to advanced molecular...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program award provides $274,990 to Dencoda LLC to develop a novel DNA-based kinase assay platform. The key products to be delivered are:
A highly sensitive, specific, and multiplexed kinase activity assay that can be used as a research tool to discover new therapeutic targets or as a clinical diagnostic test for diseases involving kinase dysregulation, such as cancers, diabetes, and Alzheimer's...
This Project Grant award from the National Institutes of Health's National Human Genome Research Institute provided $768,678 to Molecular Assemblies, Inc. to develop a fully enzymatic oligonucleotide synthesis cycle using engineered template-independent polymerases and a novel phosphate dNTP blocking group. The award supports the goals of the Human Genome Research program (CFDA 93.172) to accelerate genome research and its application to human health.
Specifically, the awardee will engineer...
This $300,000 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (CFDA 47.083) program supports research and development at the University of New Mexico (UNM) focused on computational modeling and experimental validation of DNA nanodevices. The project aims to advance simulation-guided design of DNA-based molecular systems for potential biomedical applications such as in-vivo diagnostics. Key activities include integrating high-level and low-level...
This Project Grant award from the National Science Foundation (CFDA 47.041 - Engineering) totaling $1,400,000 aims to advance the manufacturing of ultra-high-density, DNA-enabled nanoelectronics systems. The key goals are to:
Develop scalable methods for obtaining high-purity carbon nanotubes, self-aligned single-molecule junctions, and hybrid DNA nanostructures.
Establish reliable processes for integrating bottom-up and top-down architectures using field-driven directed assembly and...
This Project Grant award from the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Tectaria Bio LLC to engineer cell lines with activated proteasomes for increased biomanufacturing efficiency. The project aims to test the feasibility and application of a novel technology to significantly increase the protein production capabilities of cell lines used in the manufacture of biologics, gene therapies, and...
The National Science Foundation (NSF) awarded Pearl Bio, Inc., a biotechnology company, a $274,462 Project Grant under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The grant funded the development of a next-generation biomanufacturing platform to engineer new microbial organisms and cellular machinery. This platform enables the incorporation of diverse, non-native components into proteins, creating a new class of biological materials for therapeutic development,...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Om Therapeutics Inc. to develop innovative technology for the high-throughput screening of small molecule and protein interactions. The project aims to enable the rapid and cost-effective discovery of new medicines by encapsulating proteins and small molecules in millions of barcoded micro-compartments to identify specific...