This $900,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at the University of Colorado (CU) to investigate the molecular mechanisms of DNA methyltransferase 1 (DNMT1)-mediated gene silencing. The project aims to utilize structural biology, biochemistry, and cell biology methods to understand DNMT1 regulation and the mechanisms cells employ to ensure DNMT1 acts on specific DNA sequences. The research will provide...
This National Science Foundation Project Grant award of $292,630 provides funding for "MOLECULAR DISSECTION OF ARABIDOPSIS DNA METHYLATION MECHANISM" research being conducted at the University of Missouri-St. Louis from August 15, 2022 through November 30, 2022. The research aims to further the understanding of how DNA methyltransferase enzymes locate specific sites for methylation modification in complex genomes like plants and mammals. This has implications for genome integrity and...
The University of Missouri System was awarded a $624,059 Project Grant from the National Science Foundation Division of Integrative Organismal Systems. The grant falls under the Biological Sciences program (CFDA 47.074) to support research elucidating the mechanisms of nematode disease resistance mediated by serine hydroxymethyltransferase from November 1, 2021 to October 31, 2025. The Biological Sciences program aims to advance the field and strengthen the national scientific enterprise by...
This $452,399 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Hofstra University to investigate the epigenetic regulation of transposable elements in maize. The research aims to study the RNA-directed DNA methylation (RDDM) induced by naturally occurring maize "killer" alleles and explore the dynamic regulation of transposable element silencing in response to developmental cues. The project will...
This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
This Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $300,000 to the University of Kansas Center for Research Inc. from February 1, 2023 to January 31, 2025. The award will support research investigating delivery and trafficking of DNA introduced to cells from environmental sources using the genetically tractable organism Caenorhabditis elegans. The project aims to gain new...
This $246,424 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to define the initiation and early steps of recombination at DNA double strand breaks in human cells. The research aims to leverage novel methods to understand how cells choose different DNA repair mechanisms, with implications for fields like gene editing, cancer treatment, and personalized medicine. Additionally, the project will provide training...
This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...
This federal Project Grant award in the amount of $384,882 was provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to the University of Louisville. The funding will support research to investigate the fundamental biology and disease mechanisms of smut fungi, which are a diverse group of plant pathogens. The research aims to expand understanding of how these fungi infect and interact with their host plants, including the genetic differences that...
This $804,525 project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), will fund research exploring the epigenetic mechanisms by which ultraviolet B radiation alters DNA methylation patterns in plants. Specifically, the University of Missouri-St. Louis will investigate how UVB exposure and its photoreceptor interact to change locus- and tissue-specific DNA methylation in Arabidopsis thaliana, and how...