Project Grant 2448275
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $270,189.00 to Virginia Polytechnic Institute & State University to investigate the role of aging and type-2 diabetes on bone fracture behavior. The research program will study how changes to the collagen network in bone, such as increased crosslinking, can reduce bone's resistance to fracture in aging and diabetic populations. The project will conduct fracture experiments,...
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research to understand how human bone tissue dynamically adapts at the nanoscale level under various loading conditions. The $719,538 award to the Trustees of the University of Pennsylvania, made on May 1, 2024, will investigate the real-time rearrangement and deformation of the nanoscale components of healthy and osteoporotic bone tissue when subjected to cyclic loading....
- The National Science Foundation awarded a $280,774 Project Grant to the University of Colorado Denver under the Engineering program (CFDA 47.041) for research determining the impacts of lacunar-canalicular remodeling on bone fracture toughness. The three-year award beginning September 15, 2021 will fund collaborative research between the University of Colorado Denver's Department of Mechanical Engineering and the Regents of the University of Colorado to analyze how changes to the...
- This federal Project Grant award for $160,000.00, provided by the National Science Foundation (NSF) Office of Integrative Activities (CFDA 47.083), supports collaborative research at Boise State University to develop data-driven mechanomics capabilities for uncovering age-related mechanoregulation of bone and musculoskeletal tissues. The research aims to quantify the mechanical forces within living cells and determine how changes to these forces impact cellular protein production and...
- This National Science Foundation (NSF) Faculty Early Career Development (CAREER) Program grant, with CFDA number 47.083 - Integrative Activities, will support research to improve understanding of how osteocytes (strain-sensing cells embedded in bone tissue) regulate bone material properties and fracture resistance. The $342,516 award to Montana State University, with a period of performance from Sep 1, 2024 to Aug 31, 2029, will pursue two main objectives: 1) determining the impacts of direct...
- The National Science Foundation (NSF) Office of International Science and Engineering (CFDA 47.079) awarded a $420,000 Project Grant to Lehigh University to develop predictive computer simulation tools that can forecast bone healing progress for patients with poorly healing fractures. The 4-year project, running from October 1, 2025 to September 30, 2029, aims to create digital twin models of real bones using medical imaging data. These simulations will provide insights into individual healing...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Montana State University a $413,072 Project Grant under the Engineering (CFDA 47.041) federal grant program. The grant will fund collaborative research to determine the impacts of lacunar-canalicular remodeling on bone fracture toughness. Montana State University will lead the research as the awardee, working with partners to examine bone microstructure changes at the cellular level and their...
- This National Science Foundation (NSF) CAREER award under the Engineering program (CFDA 47.041) provides $624,622 over 5 years starting September 1, 2025 to support research aimed at advancing the scientific understanding of cartilage microstructure and function. The principal investigator will leverage quantitative magnetic resonance imaging (MRI) techniques to study how changes in the microscopic structure of cartilage impact its macroscopic behavior under loading conditions experienced in...
- This Project Grant award of $612,979.00 from the National Science Foundation's Engineering program (CFDA 47.041) supports research at Cornell University to investigate the role of acetylcholine signaling in osteocyte mechanotransduction and bone remodeling. The project aims to characterize the anatomical and functional relationship between cholinergic nerves and osteocytes, examine the acute effects of acetylcholine signaling on osteocyte calcium responses to mechanical loading, and explore...
- The National Science Foundation awarded a $514,591 Project Grant to the Regents of the University of California at Riverside under the Engineering program (CFDA 47.041) for the period of April 1, 2021 through March 31, 2026. The grant funds the CAREER: MECHANOAGING: UNDERSTANDING THE MECHANICAL FORCES THAT DRIVE CELLULAR AGING project. This project will investigate how mechanical forces impact the aging process at the cellular level. The Engineering program seeks to improve quality of life and...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports a research program at the University of Utah to investigate the biomechanical origins of bone fragility in aging and type-2 diabetic populations. The $328,416 award, spanning from July 15, 2025 to June 30, 2028, will explore how aging and diabetes-induced changes to the collagen network in bone impact its resistance to fracture at both physiological and fall strain rates. The research aims to reveal the specific mechanisms and advanced glycation end-products responsible for bone embrittlement, with the goal of supporting targeted therapeutic treatments to recover bone's fracture resistance. This work supports NSF's mission by promoting scientific progress, advancing national health, and potentially leading to improved quality of life for Americans affected by age-related and diabetes-related bone fragility.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $328.4k | 7/20/25 |