Project Grant 2448276
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports a research program at the University of Utah to investigate the biomechanical origins of bone fragility in aging and type-2 diabetic populations. The $328,416 award, spanning from July 15, 2025 to June 30, 2028, will explore how aging and diabetes-induced changes to the collagen network in bone impact its resistance to fracture at both physiological and fall strain rates. The...
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research to understand how human bone tissue dynamically adapts at the nanoscale level under various loading conditions. The $719,538 award to the Trustees of the University of Pennsylvania, made on May 1, 2024, will investigate the real-time rearrangement and deformation of the nanoscale components of healthy and osteoporotic bone tissue when subjected to cyclic loading....
- The National Science Foundation (NSF) Office of International Science and Engineering (CFDA 47.079) awarded a $420,000 Project Grant to Lehigh University to develop predictive computer simulation tools that can forecast bone healing progress for patients with poorly healing fractures. The 4-year project, running from October 1, 2025 to September 30, 2029, aims to create digital twin models of real bones using medical imaging data. These simulations will provide insights into individual healing...
- The National Science Foundation awarded a $280,774 Project Grant to the University of Colorado Denver under the Engineering program (CFDA 47.041) for research determining the impacts of lacunar-canalicular remodeling on bone fracture toughness. The three-year award beginning September 15, 2021 will fund collaborative research between the University of Colorado Denver's Department of Mechanical Engineering and the Regents of the University of Colorado to analyze how changes to the...
- This National Science Foundation (NSF) Faculty Early Career Development (CAREER) Program grant, with CFDA number 47.083 - Integrative Activities, will support research to improve understanding of how osteocytes (strain-sensing cells embedded in bone tissue) regulate bone material properties and fracture resistance. The $342,516 award to Montana State University, with a period of performance from Sep 1, 2024 to Aug 31, 2029, will pursue two main objectives: 1) determining the impacts of direct...
- This Project Grant award of $612,979.00 from the National Science Foundation's Engineering program (CFDA 47.041) supports research at Cornell University to investigate the role of acetylcholine signaling in osteocyte mechanotransduction and bone remodeling. The project aims to characterize the anatomical and functional relationship between cholinergic nerves and osteocytes, examine the acute effects of acetylcholine signaling on osteocyte calcium responses to mechanical loading, and explore...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Montana State University a $413,072 Project Grant under the Engineering (CFDA 47.041) federal grant program. The grant will fund collaborative research to determine the impacts of lacunar-canalicular remodeling on bone fracture toughness. Montana State University will lead the research as the awardee, working with partners to examine bone microstructure changes at the cellular level and their...
- This $241,823 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports the development of an implantable engineered tissue with optogenetically engineered human beta-cells. The project aims to address challenges in creating vascularized tissues with light-activatable cells to improve treatment for diabetes. Key activities include designing a gelatin-based engineered tissue with oxygen-generating microparticles and optogenetically...
- This Project Grant award from the National Science Foundation (NSF) Division of Materials Research, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $322,382 to the University of Connecticut Health Center (UCHC) from September 1, 2023 through August 31, 2026. The goals of this collaborative research project are to use computer modeling and high-energy synchrotron X-ray diffraction experiments to better understand how the incorporation of cobalt (Co) and chromium...
- This National Science Foundation (NSF) CAREER award under the Engineering program (CFDA 47.041) provides $624,622 over 5 years starting September 1, 2025 to support research aimed at advancing the scientific understanding of cartilage microstructure and function. The principal investigator will leverage quantitative magnetic resonance imaging (MRI) techniques to study how changes in the microscopic structure of cartilage impact its macroscopic behavior under loading conditions experienced in...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $270,189.00 to Virginia Polytechnic Institute & State University to investigate the role of aging and type-2 diabetes on bone fracture behavior. The research program will study how changes to the collagen network in bone, such as increased crosslinking, can reduce bone's resistance to fracture in aging and diabetic populations. The project will conduct fracture experiments, supported by advanced analytics and imaging, to reveal the specific mechanisms and advanced glycation end products responsible for bone embrittlement. The findings are expected to have significant implications for public health, particularly as diabetes prevalence rises, and could lead to the development of targeted therapeutic treatments to improve fracture resistance and quality of life. The project period runs from July 15, 2025 to June 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $270.2k | 7/20/25 |