This $612,979 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) to Cornell University aims to investigate the role of acetylcholine signaling in the function of osteocytes, which are key mechanosensors within bone tissue. The research will characterize the anatomical and functional relationship between cholinergic nerves and osteocytes, examine the effects of acetylcholine signaling on osteocyte calcium responses to mechanical loading, and evaluate the impact of acetylcholine modulation on osteocyte mechanotransduction and bone remodeling over time. This work has the potential to lead to innovative treatments for osteoporosis and other bone diseases, while also generating educational activities on biomechanics and bone health for a traveling science exhibit to serve rural communities. The award period is from January 1, 2025 to December 31, 2027.
Generated 2/25/25, 1:51 AM