This $970,670 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by the University of Cincinnati to examine how the sensory system of taste evolves in fish populations living in different aquatic environments. The researchers will analyze taste receptor genes, visualize taste bud distribution, and correlate these findings with the chemical composition of the fish's habitat. This comprehensive study aims to provide insights...
The National Science Foundation (NSF) awarded a $444,362 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Vermont & State Agricultural College, to be completed by April 30, 2027. This research project aims to investigate amino acid taste coding mechanisms and modulation in the fruit fly, Drosophila melanogaster. The primary objectives are to: 1) identify physiological factors that modulate amino acid taste response, 2) uncover the repertoire of cells and...
This $263,304 project grant award from the National Science Foundation's Biological Sciences program aims to characterize the role of the TRPM4 ion channel in taste transduction pathways. The award supports research conducted by Virginia Polytechnic Institute & State University (Virginia Tech) to investigate how TRPM4 functions in different types of taste receptor cells and its regulation within the phospholipase-C-dependent and ionotropic signaling cascades. The project will leverage...
This $353,319 Project Grant award from the Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a research project to investigate the molecular mechanisms underlying sugar sensing by insect gustatory receptors. The key objectives of the 4-year research project are to: 1) Understand how a specific insect sugar receptor, GR9 from the silk moth, binds and is activated by the sugar...
The National Science Foundation awarded a two-year, $138,000 Project Grant to support research titled "Ovposition-Relevant Gustatory Receptor Evolution as a Missing Link Governing Insect-Host Plant Specialization." The grant falls under the Foundation's Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the national scientific enterprise through increasing scientific knowledge and understanding of major problems...
The National Science Foundation awarded a $138,000 Project Grant to support research titled "The Insatiable Sweet Tooth: Molecular Adaptations to Nectarivory in Mammals" from July 1, 2021 to June 30, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote advancement in the biological sciences and strengthen the national scientific enterprise through increasing knowledge and understanding of major issues facing the country. Funding will...
The National Institute of General Medical Sciences (NIGMS) awarded a $370,851 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to Vanderbilt University Medical Center. The project, titled "Maintenance of Brain Homeostasis by an Ancient Zinc Metallochaperone," aims to determine the impact of the zinc metallochaperone protein ZNG1 on transcription factor activity and signaling pathways important for neuronal development, response to stress, and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,159,930.00 in funding to the Research Foundation for the State University of New York (RF SUNY) over the period of Jul 1, 2024 to Apr 30, 2029. The primary objective of this research project is to investigate how salivary zinc modifies the activity of the antimicrobial protein histatin 5 towards the...
This $386,034 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to determine how bitter taste receptors (TAS2Rs) in gut 'neuropod' cells detect bitter compounds and signal this information to the brain via the vagus nerve. Specific aims include characterizing TAS2R expression and signaling in neuropod cells, and...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $750,000 from July 15, 2024 to June 30, 2028 will support research conducted by the University of Nevada, Reno (UNR) to investigate how an insect's hunger state affects its sense of smell and navigational decision-making. The project aims to enhance understanding of how hunger-related signaling, such as insulin, modulates the activity of key inhibitory neurons in the insect brain to...