The University of California, San Diego (UCSD) has been awarded a $1,422,000 Project Grant by the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program. The research project, titled "Probing Sex Differences in Myocardial Fibrosis at Multiple Length Scales Using Biomaterials," aims to investigate how biological sex modulates myocardial fibrosis and develop innovative models of sex-specific tissue remodeling using advanced biomaterial...
This Project Grant award from the National Science Foundation (NSF)'s Engineering program (CFDA 47.041) will fund research and development of sex-based human cell culture methods and microphysiological systems at Tulane University. The $225,281 award, effective July 1, 2025 through June 30, 2030, aims to develop female (XX) and male (XY) cell culture media formulations with defined sex hormone compositions, as well as engineered tissue models for studying sex differences in cellular...
This $600,019 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research effort led by New York University (NYU) to investigate the structure and function of the X chromosome, with a focus on the process of X-chromosome inactivation. The research team, which also includes researchers from Harvard University and the New Mexico Consortium, will integrate high-resolution genomics data with advanced spatial modeling to...
The University of Colorado was awarded a $1,944,807 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the role of inflammation and biological sex on aortic valve fibrocalcification. The project aims to develop sex-specific in vitro models to study the mechanisms underlying sex differences in the progression of aortic valve stenosis, a common cardiovascular condition. Key research activities include investigating the...
This $148,568 federal Project Grant awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of inflammation and sex-specific differences in the progression of aortic valve stenosis (AVS). The key objectives are to: 1) delineate how secreted factors from valve cells impact macrophage phenotype and vice versa in a sex-dependent manner, and 2) elucidate sex-specific differences in AVS...
This federal Project Grant award of $899,982 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research effort to study X-chromosome inactivation and genome organization in human cells. The research team from New York University, Harvard University, and the New Mexico Consortium will integrate advanced genomics data, computational modeling, and biophysical approaches to unravel the complex folding of the X-chromosome and its impact on...
This $149,999 Project Grant award from the National Science Foundation's Integrative Activities (CFDA 47.083) program will support a collaborative research effort to model X-chromosome inactivation in human cells. The principal investigators from New York University, Harvard University, and the New Mexico Consortium will leverage expertise in molecular biology, genomics, computational biology, biophysics, and biomolecular modeling to investigate the complex genome organization and epigenetic...
This $649,992 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to investigate the mechanics and structure of aortic valve leaflets and the formation of microcalcifications, which contribute to calcific aortic valve disease. The research team at the University of Wisconsin-Madison will develop new methods to measure spatially-varying material properties of aortic valve leaflets over time, and use advanced imaging to study the...
This $153,512 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Program (CFDA 93.837), aims to investigate how the mechanical properties of cardiac tissue, specifically elasticity and viscosity, modulate the interactions between macrophages and fibroblasts in the context of cardiac fibrosis. The award recipient, the University of California, San Diego (UCSD), will develop an engineered cell culture system to study...
The National Science Foundation awarded a $279,606 Project Grant to the University of California Irvine under the Engineering federal grant program (CFDA 47.041). The grant supports collaborative research to develop multiscale computational models characterizing how heart muscle cells adapt mechanically to changes in load conditions. Through experimental measurement and multi-scale modeling, the university researchers will elucidate the acute functional response and long-term remodeling response...