Project Grant 2442158
- The U.S. National Science Foundation (NSF) awarded a $426,000 project grant under the Mathematical and Physical Sciences (CFDA 47.049) program to The Regents of the University of California, San Francisco (UCSF) to conduct collaborative research on developing novel protein-based materials for photosynthetic energy transduction. The multi-year project, led by Professors Michael Therien and David Beratan of Duke University and William DeGrado of UCSF, aims to design and construct protein-based...
- This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
- This Project Grant award of $924,000.00 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by Professors Michael Therien and David Beratan of Duke University and Professor William DeGrado of the University of California San Francisco. The goal of this research is to develop new protein-based materials capable of harvesting, storing, and releasing energy in ways that mimic the sophisticated energy...
- This $480,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of novel approaches for assembling three-dimensional protein biomaterials. The primary goal is to create "coordinated protein frameworks" (CPFs) - extended protein lattices with defined geometries and tunable distances between the assembled proteins. This work leverages non-canonical amino acids to precisely control the...
- The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal control...
- This $539,895 federal Project Grant award from the National Science Foundation's (NSF) Division of Materials Research Solid State and Materials Chemistry Program supports research to develop well-defined, stimuli-responsive materials with fast and reversible photophysical properties. The 3-year project, running from 09/01/2025 to 08/31/2028, aims to advance fundamental understanding of synthesis approaches that enable orthogonal or cooperative control over material properties in response to...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $206,912 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of North Carolina at Chapel Hill. The three-year grant, effective August 1, 2023 through July 31, 2026, supports collaborative research to enhance the understanding of protein structures and behaviors at extreme temperature and pressure conditions. The research aims to develop rules for predicting protein...
- This Project Grant award of $1,500,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research to elucidate the design principles for de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key products and services to be delivered include: (1) Development of de novo designed proteins that can be readily transformed into junctions within polymer networks. (2) Investigation of the use of de novo...
- The University of North Carolina at Chapel Hill will receive $495,000 from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to support research into designing artificial enzymes from June 2022 to May 2025. Dr. Albert Bowers and his team will develop a generalizable strategy for separating substrate binding and catalysis functions into distinct domains for peptide-based enzymes. They will use computational protein design with Rosetta to create...
This $500,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will fund Dr. Nicholas Truex at the University of South Carolina to investigate synthetic protein switches. The research aims to characterize the molecular interactions that enable these proteins to adopt two distinct folded structures, utilizing non-natural amino acids to dissect their conformation and stability. Key experimental techniques will include circular dichroism, differential scanning calorimetry, NMR spectroscopy, and molecular modeling. The project also includes educational and outreach components, providing training for graduate, undergraduate, and high school students in areas such as automated flow protein synthesis, physical biochemistry, spectroscopy, and molecular modeling. Additionally, the project will implement a new K-12 STEM education outreach program called "Hidden Chemical Properties" and support the American Chemical Society Project SEED mentorship program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 7/16/25 |