Project Grant 2440762
- The National Science Foundation awarded a $367,636 Project Grant to the Massachusetts Institute of Technology from March 1, 2021 through February 29, 2024 under the Biological Sciences program (CFDA 47.074). The grant funds collaborative research on multidimensional single-cell phenotyping to elucidate relationships between genomes and phenotypes. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research. This award supports...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award, valued at $570,122.00 and effective September 1, 2024, supports a collaborative research effort to investigate innate immune responses in diverse eukaryotic organisms that consume bacteria. The project brings together a cross-disciplinary team of researchers to study innate immunity in sponges, choanoflagellates, and amoebae, which span the evolutionary transition between multicellular animals and their...
- This $1,714,712 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research to critically evaluate the ecological and functional drivers of polyploid establishment in plants. The project aims to use population-level experiments with a model aquatic species under varied stresses to elucidate the mechanisms that allow polyploid species to thrive, especially in stressful habitats. The research will contribute to understanding the formative...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal project grant award provides $1,100,000 to the University of Massachusetts Medical School (UMMS) to systematically investigate a novel bacterial DNA-targeting immune system known as DDMDE. The project aims to transform genome editing capabilities by revealing how DDMDE identifies target DNA sequences and recruits partner enzymes to cut unwanted DNA, without relying on the genetic signatures required by CRISPR....
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- The National Science Foundation awarded a two-year Project Grant of $138,000 to Quincy, Massachusetts from July 1, 2021 to June 30, 2023 under the Biological Sciences program (CFDA 47.074). The grant will support modeling of the singular and additive effects of various anthropogenic disturbances on genetics using genomics. Most research funded under the Biological Sciences program aims to advance the fundamental biological sciences and enhance understanding of major problems to strengthen the...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $1,000,000 to the University of Michigan provides funding from August 1, 2024 to July 31, 2028 to study the molecular mechanism of telomere maintenance in the model organism Caenorhabditis elegans. The research aims to leverage the simplicity of the worm's shelterin protein complex to answer fundamental questions about the structure and function of these proteins in chromosome end protection and...
- This federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $584,772 to Trustees of Boston University to develop new light-based tools for monitoring infection progression and host immune responses in living fruit flies (Drosophila). The goal is to uncover genetic and environmental factors that influence infection outcomes by tracking microbial dynamics and host immune responses over time in individual animals. The research...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program has awarded a $1,039,048 Project Grant to the University of North Carolina at Chapel Hill (UNC-CH) for the project "CAREER: Stress, Recovery, Regeneration, and Resilience in Reproduction". The project will use a short-lived worm model organism to investigate how animal cells and organs respond to starvation at different ages, and how those responses affect the animal's ability to reproduce...
This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund an integrated research and educational project at Boston College. The project, titled "CAREER: Discovering the Interplay Between Polyploidy and Innate Immunity," aims to yield fundamental knowledge on how wound healing is regulated by cell growth and its contribution to an animal's defense against infection. The project will train graduate and undergraduate students in laboratory and classroom settings, providing hands-on research experience in cell biology, genetics, and microbiology. Key activities include teaching over 120 students per year in an introduction to genetics course how to conduct, score, and identify mutants from a genetic screen to reveal new regulators of cell growth and wound healing. The findings from this research are expected to identify novel therapeutic targets to improve human health and prevent disease, and the scientific and educational discoveries will be shared with the public to enhance scientific communication, discovery, and rigor in STEM fields. The award period runs from August 15, 2025, through July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 7/28/25 |