This $325,000 federal Project Grant award was provided by the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) to the University of Mississippi to support a research project titled "DECIPHERING INTERCONNECTIVITY BETWEEN CELL CYTOSKELETON FORCES, MECHANICS, AND MACHINERY". The primary objectives of this 5-year research project are to: (1) evaluate how myosin ensemble synergy is influenced by soluble mechanical modulators, (2) understand how the mechanosensitive environment within the cytoskeletal network affects myosin force generation, and (3) investigate how the stiffness of the environment changes force output of motor protein ensembles. This research aims to advance the field of biomechanics and mechanobiology by revealing how motor proteins work together and adapt to mechanical signals within cells. The project will involve engineering customizable cytoskeletal ensembles in vitro and investigating their behavior using optical tweezers, fluorescence imaging, and a quartz crystal microbalance. This research has the potential to enable construction of minimalistic cell models, contribute to creating biomimetic smart materials, and elucidate mechanisms of diseases relying on mechanical feedback. No subawards are planned under this award.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $325.0k | 1/16/25 |