Project Grant 2246970

Award Date 10/1/22
Completion Date 4/30/23
Dollars Obligated $148K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Columbus, OH 43210, USA
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The funding will support research investigating how mechanical forces are transmitted within cells through the linker of nucleoskeleton to cytoskeleton (LINC) complex. The principal investigator will develop novel force biosensors for LINC complex proteins nesprin and SUN to study the mechanical and force-dependent biochemical processes associated with the LINC complex. This could help validate or advance theories of cellular biomechanics by providing a better understanding of how forces are transmitted within a cell. Undergraduate and graduate students will engage in interdisciplinary research projects supported by this award. Outreach to K-12 students is also planned.

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