This $322,978 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program supports research to enhance the capabilities of the recently developed E3-DART plant protein degradation system. The project aims to 1) develop a ligand-inducible version of E3-DART, 2) create additional recombinant tools to control E3-DART activity, and 3) demonstrate proof-of-concept applications of E3-DART to study endomembrane protein function and secretory...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award of $337,667 to North Carolina State University (NC State) aims to enhance a recently developed protein degradation system called E3-DART, which can be used to control the abundance of proteins in plant cells. The key objectives are to: 1) develop a ligand-inducible version of the E3-DART system, 2) create additional recombinant tools to control E3-DART activity, and 3) demonstrate proof-of-concept...
This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
This $1,150,000 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program supports the development and sharing of high-resolution in situ 3D cryo-imaging workflows to transform plant cell biology research. The award recipient, the Donald Danforth Plant Science Center, will use the funding to advance cryogenic preservation and nanoscale imaging techniques for visualizing the native structure of plant cells and organelles using volume...
This $950,000 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Purdue University from April 1, 2023 to March 31, 2027. The research aims to advance understanding of specialized vesicles derived from the endoplasmic reticulum in plants and their role in protein trafficking and biological functions. Specifically, the university will investigate the functional diversity of vesicles containing NAIP proteins, identify their cargo...
This $977,252 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to examine the mechanisms plants use to control the patterning of cellulose fibers in their cell walls, which determines plant morphology. The research focuses on investigating how microtubule polymers on the inside of plant cells form patterns that guide the deposition of cellulose on the cell exterior. Advanced imaging, genetic, and computational modeling...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program project grant awarded to Trustees of Dartmouth College will provide $270,241 from June 1, 2025 to May 31, 2030 to characterize evolutionarily conserved plant signaling modules that underlie organ development. The project will investigate how small molecules made by plants orchestrate organ formation, using the non-seed model plant species Physcomitrium patens and CRISPR-Cas9 genome editing. This research aims to...
This National Science Foundation (NSF) Project Grant under the Biological Sciences program (CFDA 47.074) will fund research at Dartmouth College to investigate how plants integrate signals related to iron availability and light conditions. The $809,225 award made on March 1, 2024 will support experiments to understand the role of the URI protein in regulating iron uptake and utilization by plants. The research aims to improve understanding of how plants coordinate their responses to iron...
The National Science Foundation (NSF) awarded a $299,772 EAGER (Early-concept Grants for Exploratory Research) grant under the Biological Sciences program (CFDA 47.074) to Washington State University (WSU) to develop new molecular tools for identifying protein-protein interactions within specific cellular compartments in plant cells. The project, titled "TOOLS4CELLS: Bimolecular Proximity Tagging", aims to close the gap in existing methods by creating split enzyme versions that can map...
This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...