The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) awarded a $429,999 project grant to The Regents of the University of California, San Francisco (UCSF) to develop a novel method for modifying cellular signaling pathways using implanted electronic circuits. The 2-year project aims to create microelectronic chips that can be inserted into living cells to sense biochemical signals, release genetic material or small molecules, and effectively "rewire" cellular networks under electronic control. This proof-of-concept research could enable more rigorous testing of intracellular signaling models and lead to new ways of studying and manipulating complex cell behaviors, with potential applications in basic biology, biotechnology, and semiconductor technology. The project also includes plans to provide cross-training opportunities for students in both cell biology and electrical engineering to foster interdisciplinary workforce development.