This National Science Foundation (NSF) CAREER award, under the Mathematical and Physical Sciences (CFDA 47.049) program, aims to develop a novel approach to engineer liquid-liquid phase separation and microstructural heterogeneity in polysaccharide-based hydrogels. The $152,007 project, awarded on January 15, 2025, with a completion date of December 31, 2029, seeks to create customizable hydrogel materials through a simplified "bottom-up" process that eliminates the need for organic...
The University of Maine was awarded a $299,589 project grant from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program. The grant will support research exploring nanocellulose based foams for low-cost, single-use, biodegradable medical patient support and positioning applications from July 15, 2021 to June 30, 2023. The NSF Technology, Innovation, and Partnerships program seeks to advance science, engineering, and technology solutions to national...
This $200,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of innovative fluorinated protein fibers and hydrogels for medical applications at New York University (NYU) School of Medicine. The key objectives are to: 1) generate coiled-coil fluorinated fibers for controlled drug delivery, 2) create temperature-responsive fluorinated hydrogels, and 3) assess the potential of these fluorinated...
This $285,570 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at the University of Vermont & State Agricultural College (UVM) to investigate living tissues as adaptive materials. The project aims to understand how cellular adaptability influences the mechanical properties and behaviors of tissues, with potential applications in areas like wound healing, cancer, and the development of biomimetic materials.
The research will...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to:
Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions.
Directly relate the observed domain unfolding of...
This $365,566 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of a versatile, DNA-based synthetic extracellular matrix (ECM) that can mimic the intricacies of biological systems. The goal is to create a controllable and biocompatible ECM mimic that can enhance regenerative medicine applications and provide insights into cell biology and ECM interactions.
The key...
This Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, aims to develop innovative protein-based biomaterials through a directed evolution approach. The $1,500,000 award to Northwestern University, spanning from October 2024 to September 2027, seeks to (1) engineer mussel foot proteins with superior underwater adhesion properties compared to wild-type sequences, and (2) design resilin-inspired bioelastomers...
This $394,704 National Science Foundation Integrative Activities Project Grant supports the design and characterization of biofilm-inspired amyloid biomaterials at The University of Southern Mississippi from August 1, 2022 to July 31, 2025. The grant aims to establish relationships between protein sequence, structure, processing, and material properties through a series of de novo peptides designed to mimic curli amyloid sequences. Researchers will synthesize peptides and characterize their...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award in the amount of $169,525 was made on October 1, 2024 to the University of New England. The award supports the development and validation of a "joint-on-a-chip" microphysiological system (MPS) to serve as an innovative model for early-stage pharmaceutical drug testing and osteoarthritis research. The project aims to establish an in vitro system that can efficiently...
This $109,940 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) will enable the University of Connecticut to deliver a Biomaterials and Bioprinting Summer School research and mentoring program. The program will provide hands-on research experience and training in tissue engineering to high school and undergraduate students from underrepresented minority groups. Participants will develop strategies for designing biomaterial structures and tissues. They will...