The National Science Foundation (NSF) awarded a $1,000,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Delaware. The goal of the research, titled "TOOLS4CELLS: REALTIME METABOLITE SENSING AND METABOLON FORMATION VIA BIOMOLECULAR CONDENSATES," is to develop new strategies for real-time metabolite sensing and metabolite-responsive control of cellular metabolism. The project aims to create synthetic protein-based devices that can translate metabolite-induced DNA binding into reversible protein condensate formation, enabling sensitive, real-time biosensing of intracellular metabolites. The research also seeks to exploit the reversible nature of these protein-DNA interactions to dynamically assemble metabolons, which will provide metabolite-responsive control of cellular metabolism. This work is expected to significantly impact the field of synthetic biology by advancing methods for real-time metabolite sensing and metabolite-mediated enzyme localization across various organisms. The grant was awarded on August 15, 2024, with a projected completion date of July 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.0m | 8/6/24 |