The Johns Hopkins University received a $1,320,970 Project Grant from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) to research the periplasmic chaperone network organization and mechanism in bacteria. The project aims to uncover the fundamental physical principles that define the rules of life in bacteria, with a focus on the essential process of bacterial cell surface formation. The research will employ a multi-scale approach including structural measurements, solution conformation analysis, computational modeling, and in vivo localization studies to develop a systems-level understanding of the chaperone network in the bacterial periplasm. The grant, awarded from October 1, 2024 through September 30, 2028, is expected to yield insights into bacterial life processes that could benefit studies of higher life forms. The research activities will also provide meaningful training opportunities for undergraduate and graduate students, contributing to the development of a diverse and creative STEM workforce.
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