This federal Project Grant award of $116,354, provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049), supports collaborative research to develop a mathematical theory for the biological concept of modularity. The research aims to define modular structures in biological systems, such as gene regulatory networks underlying salamander limb regeneration and hormone regulation in plants, in a...
This $210,720 federal project grant was awarded by the National Science Foundation (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The project aims to define modular structures in biological systems in a mathematically rigorous way, and determine how modularity can be advantageous to organisms and advance the understanding of molecular systems. The research will study the modularity of gene regulatory networks underlying...
This $750,000 Project Grant award from the National Science Foundation (CFDA 47.074 Biological Sciences) will support collaborative research at the University of Iowa on the evolution and development of fundamental plant reproductive structures called sporangia. The research aims to investigate the molecular genetics of sporangium development in the model fern Ceratopteris, in order to better understand the evolution of sporangia across land plants and fill a knowledge gap about plant...
This $196,472 Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research by Northwestern University to develop a systematic framework for predicting how biological fitness in eukaryotic model systems is influenced by combinations of mutations and environmental factors, including genetic, chemical-genetic, and drug-drug interactions. The overarching goal is to break down barriers in understanding higher-order...
Iowa State University of Science and Technology (ISU) was awarded a $796,021 Project Grant from the National Science Foundation on February 15, 2021 to complete work by January 31, 2024. The grant supports ISU's project "Regulatory Networks that Control Autophagy to Enable Environmental Stress Resilience in Plants" under the Biological Sciences program (CFDA 47.074). The project aims to increase scientific understanding of major problems confronting the nation by promoting progress...
This $290,025 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to develop new methods for detecting eukaryotic symbionts associated with insects. The primary awardee, the University of Iowa, will use the funding to: 1) design PCR blocking primers to inhibit amplification of insect DNA while allowing detection of other eukaryotic organisms, and 2) conduct large-scale surveys of insect-symbiont diversity across two...
This $959,997 federal Project Grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), supports collaborative research at the Cold Spring Harbor Laboratory to develop improved methods for plant transformation and regeneration. The research aims to provide a thorough understanding of the molecular mechanisms underlying regeneration in maize, a key crop that provides a substantial portion of human caloric intake. By exploiting a "morphogenic-based"...
This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
This Project Grant from the National Science Foundation's Division of Environmental Biology, under the Biological Sciences program (CFDA 47.074), provides $241,585 to Iowa State University to synthesize 25 years of research in permutational biometry and develop new analytical tools for biological data analysis. Specifically, the investigators will produce a full-length book and web-based tutorials integrating their work in resampling of residuals in a permutation procedure, permutation-based...
This Project Grant award, valued at $257,591, was provided by the National Science Foundation's (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The award supports a collaborative research project between the University of California-Riverside and the University of Notre Dame to develop data-driven, multi-scale mathematical and computational models for investigating the critical signaling pathways and biophysical mechanisms...