This National Science Foundation (NSF) Career Award, under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program, supports research at Northwestern University to develop a systematic framework for predicting how biological fitness in eukaryotic model systems is influenced by combinations of mutations and environmental factors. The $196,472 award, effective February 1, 2025 through January 31, 2030, will enable the creation of a versatile hypergraph framework to model both pairwise and higher-order genetic, chemical-genetic, and drug-drug interactions. The research aims to address critical knowledge gaps that prevent linking genotype to phenotype and identifying therapeutic biomarkers for complex diseases. The project will also expand the university's high school outreach activities and organize community art exhibits showcasing the aesthetic beauty of biological networks. This award reflects NSF's mission to advance scientific knowledge and support innovative research with potential for meaningful societal and technological impacts.
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