This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant of $274,829 awarded to Rosebud Biosciences Inc. on August 15, 2023 aims to enable the development of new therapies for rare diseases in children. The project objectives are to: (1) Automate the derivation of heart, liver, and brain organoids from human stem cells, and (2) Develop automated machine learning models to detect disease phenotypes in these organoids derived from patients with...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Beken Bio, Inc. aims to develop a highly sensitive, minimally invasive laboratory test to detect early-stage ovarian cancer by assaying relevant biomarkers on circulating extracellular vesicles in patient plasma. The project will utilize a novel technology to identify key proteins in extracellular vesicles from various ovarian cancer subtypes and employ a machine...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Cerflux Inc. aims to develop a personalized cancer treatment screening platform. The project will establish guidelines for handling solid tumor biopsy samples, generate 3D bioprinted tumor models for validation, and demonstrate the platform's ability to match patients with the most effective cancer treatments before treatment begins. This innovative approach has the...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) project grant, awarded to Worcester Polytechnic Institute (WPI), will develop in vitro models to study fibrosis progression and regression across different tissue types, including the pancreas, skin, and uterine fibroids. The $629,998 award, running from June 1, 2025 to May 31, 2030, will enable WPI to engineer these tissue-specific models to investigate how extracellular matrix properties, cellular composition, and...
This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Foragr Medicines, Inc. to develop a high-throughput platform for small molecule, in-cell targeting of undruggable proteins via their mRNAs. The project aims to improve the health and welfare of Americans by providing an efficient and cost-effective approach for developing therapeutics for previously undruggable diseases, including...
This is a Project Grant award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to Core Biotherapeutics Inc., a small business in Ladera Ranch, CA. The $303,864 award, effective April 1, 2025 through March 31, 2026, supports the development of a platform to identify molecular network drivers of diseases and program them into an algorithm for drug target discovery. The goal is to create a scalable, network-based approach to develop...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Brainstorm Therapeutics, Inc. aims to develop and validate a novel Parkinson's disease drug discovery platform using patient-derived midbrain organoids. The platform will guide therapeutic candidate identification, patient selection, and trial endpoint refinement to accelerate the development of effective disease-modifying Parkinson's treatments. Key innovations...
This $274,594 Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports research and development of an innovative technology for cancer diagnosis and treatment. The project aims to improve molecular profiling and clinical laboratory testing of cancer samples by optimizing microdissection techniques. The research will focus on modeling and optimizing the opto-thermal-mechanical interactions involved in microdissection to...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $305,000 to Sostos Inc., a minority-owned and woman-owned small business, aims to develop a cloud-based software platform to identify multi-omics biomarkers for guiding non-small cell lung cancer treatment decisions. The proposed technology utilizes advanced AI techniques to model complex molecular interactions and gene regulatory networks, enabling the discovery of biomarkers...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $303,445 to Endura Therapeutics Inc. aims to develop a next-generation sequencing platform for discovering small molecules that target RNA. The project seeks to address two key challenges: demonstrating that small molecules can modulate protein expression by binding to messenger RNA, and creating a high-throughput screening method to identify such molecules and their optimal RNA...