Project Grant 2432856
Award Date
1/15/25
Completion Date
12/31/25
Dollars Obligated
$275K
Federal Agency
National Science Foundation
Federal Grant Program
47.084
Assistance Type
Project Grant
Place of Performance
Research Triangle Park, Durham, NC, USA
Similar Awards
This Project Grant award of $303,445 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of a next-generation sequencing platform for discovering small molecules that target RNA. The project aims to address the challenge of identifying RNA-binding small molecules capable of modulating protein expression, which could enable therapeutic interventions for diseases currently lacking treatment options, such as...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $303,864 to Core Biotherapeutics Inc. aims to develop a platform for disruptive drug candidates that can reprogram molecular networks to produce therapeutic effects beyond single-target approaches. The key objectives are to: 1) demonstrate that oligonucleotide drug efficacy is a function of transcription factor (TF) network reprogramming using a breast cancer cell line, 2) build a...
This Project Grant award of $275,000 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of a novel platform for massive, empirical, and scalable generation of small molecule and protein interaction data. The goal is to enable more efficient discovery of new medicines using machine learning. The key products and services to be delivered under this SBIR Phase I award include: Demonstrating the ability to identify...
This Project Grant award from the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Tectaria Bio LLC to engineer cell lines with activated proteasomes for increased biomanufacturing efficiency. The project aims to test the feasibility and application of a novel technology to significantly increase the protein production capabilities of cell lines used in the manufacture of biologics, gene therapies, and vaccines....
The National Science Foundation (NSF) awarded a $274,640 Project Grant under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to Protein Design Solutions LLC, a for-profit limited liability company located in Allentown, PA. The grant funding will support the development of a computational platform to predict and mitigate protein aggregation issues in the development of protein-based therapeutics. Specifically, the project aims to leverage state-of-the-art...
This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program) provides $275,000 to Ubiquitx Inc., a New York-based small business, to develop a programmable, modular therapeutic platform for the direct modification of proteins of interest (POIs) using artificial intelligence, protein engineering, and mRNA therapeutics. The goal is to expand the applications of the company's Chimeric Ligands for Induced Proximity (CLIPS)...
This $305,000 Small Business Innovation Research (SBIR) Phase I project awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) aims to develop a new class of gene therapies delivered more safely, cost-effectively, and at scale for serious genetic disorders. The project leverages short oligonucleotides conjugated with small molecules to induce proximity of endogenous epigenetic machinery to disease-relevant genes,...
This $274,797 National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award to Deepseq.ai LLC supports the development of an AI-driven platform to accelerate the identification of highly developable single-domain antibodies for drug discovery. The proposed work aims to create a multimodal AI model capable of rapidly screening large libraries to generate lead molecules with favorable binding affinity, stability, and manufacturability. This project...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $304,995 to Multitarga LLC will develop an adaptive multi-targeted priming platform called HostPathEP to enhance the sensitivity and specificity of RNA sequencing for pathogen detection. The project aims to overcome limitations in current transcriptomic assays by designing customized reagents to differentiate low-abundance pathogen transcripts from host background. The anticipated...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,932 to Femtofluidics Incorporated aims to develop hardware that will enable the rapid and inexpensive synthesis of DNA-encoded libraries (DELs). The goal is to expedite drug discovery and generate data to train artificial intelligence (AI) models, strengthening U.S. competitiveness in drug discovery and reinforcing leadership in automation and AI research. The technology will...