The National Science Foundation awarded a $587,853 Project Grant to The Research Foundation For The State University Of New York to fund research into the mechanics of cortical folding patterns in the developing human brain. The three-year award runs from July 1, 2021 to June 30, 2024 under the NSF Engineering program (CFDA 47.041). The grantee and sub-awardee, Boston Children's Hospital, will conduct research to improve understanding of how patterns in the cerebral cortex form during human...
This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program provides $449,935 to Appalachian State University to study the role of tissue mechanics in brain folding during development. The research project will use the mouse cerebellum as a model system to investigate how growth rates, tensile forces, and material properties of developing brain tissue interact to induce and shape patterns of brain folding. The project aims to advance...
This National Science Foundation Project Grant of $266,014 awarded on February 15, 2022 supports research into the developmental mechanics of brain evolution under the Mathematical and Physical Sciences program (CFDA 47.049). Specifically, the funding enables a collaborative US-France study between Harvard University and partners in France to advance understanding of the role of genetic and mechanical factors in brain cortical folding patterns across species. Using comparative phylogenetic...
The National Science Foundation awarded a $118,212 Project Grant to the University of Delaware under the Integrative Activities (IA) program (CFDA 47.083) to conduct fundamental research on the extreme mechanics of the human brain. The research combines high-rate mechanical testing, analytical and computational modeling, and machine learning to generate insights into how the living human brain responds to large and rapid loading. This work will contribute to the fields of tissue mechanics,...
This $1.5 million Project Grant from the National Science Foundation (NSF), under the Engineering federal grant program (CFDA 47.041), will fund research at the University of California Irvine from October 2022 through September 2026. The university will develop hydrogel-based bioengineering technologies to reproducibly generate distinct spatial organization and cellular diversity within cortical organoids, mimicking the development of different brain regions. Researchers will leverage expertise...
This $300,000 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) will support research at the University of Pittsburgh to develop new analytical tools and computational models to understand how the brain selectively processes relevant information and coordinates information flow across brain regions. The project aims to integrate existing datasets on large-scale neural activity and anatomical connectivity...
The National Science Foundation (NSF) awarded The Johns Hopkins University a 3-year, $274,297 Project Grant under the Engineering program (CFDA 47.041) to conduct collaborative research on the extreme mechanics of the human brain. The research aims to generate insights into how the living human brain responds to large and rapid loading, which is critical for developing models to predict traumatic brain injury and designing safer protective equipment. The project will combine high-rate mechanical...
This $370,687 federal Project Grant award, funded by the National Science Foundation (NSF) Computer and Information Science and Engineering (CFDA 47.070) program, will support a multiscale modeling and analysis framework to study the brain and its disorders, with a focus on understanding neural mechanisms in autism. The project aims to develop an integrative modeling approach that links cellular-level mechanisms to whole-brain dynamics, using a combination of spiking neural networks and neural...
This National Science Foundation Project Grant, awarded under the Engineering program (CFDA 47.041), provides $206,132 to Louisiana State University to conduct fundamental research on the high strain rate mechanics of the human brain. The research aims to develop advanced computational models and experimental techniques to better understand the complex mechanical behavior of the living human brain under extreme loading conditions, such as those encountered during traumatic brain injuries. The...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...