This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) is focused on understanding the physical factors that limit how individual cells and groups of cells respond to electric fields, and how this relates to wound healing. The $108,811 award to Princeton University, with a period of performance from August 15, 2024 to July 31, 2027, will support the development of computational models examining the motion of sensor molecules...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049) provides $380,000 to Northeastern University to develop a new generation of computational models for studying eukaryotic cell motility. The research aims to better understand how cells move through complex tissues, which is critical for both healthy developmental processes and the spread of cancer. The project will involve a collaborative effort between...
The National Science Foundation (NSF) awarded a $380,000 Project Grant under the NSF Engineering program (CFDA 47.041) to The Johns Hopkins University in Baltimore, Maryland. The purpose of this 3-year award, with a start date of July 1, 2024, is to develop methods to enable feedback control over electric field-mediated assembly of supported membranes from porous particles of different shapes and materials. The key objectives are to: (1) measure and model the dipolar interactions of porous...
The National Science Foundation (NSF) Division of Physics awarded a $599,963 Project Grant to Duke University's Office of Research Administration Division to study the mechanosensitivity of the membrane-actin cortex interface in human and animal cells. This 3-year grant, running from August 2023 to July 2026, will develop innovative biosensors to investigate how the ezrin protein, which is involved in stem cell differentiation and cancer progression, responds to physical forces at the cell...
This federal Project Grant award, provided by the National Science Foundation (NSF) through its Biological Sciences program (CFDA 47.074), supports fundamental research on the periplasmic chaperone network in bacterial cell surface formation. The $1,320,970 award to The Johns Hopkins University will investigate the physical principles and mechanisms governing this essential cellular process in bacteria, one of the most abundant forms of life on Earth. The multi-scale research approach will...
This National Science Foundation Project Grant of $419,750 will fund research at Washington University in St. Louis from August 1, 2022 to July 31, 2025 to study how living cells move across dissimilar physical environments and retain mechanical memories of prior environments. Specifically, the award will integrate experiments and computational modeling to examine how forces generated by cells modify their surroundings in two mechanically different environments during migration. This will reveal...
The Johns Hopkins University was awarded a $425,000 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems to support research titled "FIELD MEDIATED ASSEMBLY OF ANISOTROPIC COLLOIDS ON SURFACES" from July 1, 2021 to June 30, 2024. Under this award, The Johns Hopkins University will conduct research focused on controlling the assembly of anisotropic colloidal particles on surfaces using external fields. This work...
This Project Grant award for $479,487 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at The Johns Hopkins University to investigate how key physical cues, such as extracellular fluid viscosity, microenvironmental stiffness, and cellular confinement, regulate cell migration and function. The research aims to develop a comprehensive understanding of how these...
This National Science Foundation Project Grant of $492,743 will fund research into the impacts of intracellular and extracellular hydraulic environments on mammalian cell migration in confined spaces. Awarded on October 15, 2022 under the Engineering program (CFDA 47.041), the funding will support mathematical modeling to decipher the coupled effects of fluid interaction with cellular structures on cell behavior in confined migration. The awardee, the Research Foundation for the State University...
This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $199,982 to Wesleyan University to investigate the principles governing the interactions at the interface between different groups of cells. The research aims to understand how cells from different tissues interact and organize themselves when they come into contact, which is crucial for processes like tissue development, wound healing, and cancer metastasis. The project will use...