Project Grant 2403583

Award Date 8/15/24
Completion Date 7/31/27
Dollars Obligated $489K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Ann Arbor, MI 48109, USA
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The development of an integrated platform consisting of seven web servers and three large databases to enable exploration of the structural and dynamic aspects of biomolecules in membranes. The web servers will provide capabilities for all-atom modeling and analysis of folding, stability, conformational positioning, and molecular interactions of proteins and peptides in membranes, as well as calculating membrane permeability coefficients and translocation pathways across lipid bilayers for small molecules and peptides. The databases will be expanded to include a comprehensive set of experimental structures of membrane proteins and peptides, as well as in silico models of single-pass transmembrane proteins and permeability data for small molecules. The goal is to create an integrated, easy-to-use platform that serves as a valuable research resource, educational tool, and public engagement instrument for cutting-edge biomembrane research.

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