This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) project grant of $1,117,707 awarded to the University of South Carolina aims to better understand how organisms integrate the essential metal iron with core metabolic pathways. The project will use E. coli as a model organism to examine the molecular details of iron-sulfur (Fe-S) cluster formation and trafficking, including the role of monothiol glutaredoxins in this process and their interactions with proteins involved in cell envelope biogenesis. The research will combine microbial genetics, analytical chemistry, protein biochemistry, and quantitative mass spectrometry to provide insight into the crosstalk between Fe-S cluster biogenesis and cell envelope biogenesis. The project also includes a subgrant to Boston College to perform proteomic analyses. This research is expected to advance scientific understanding of cellular iron utilization and its connection to essential metabolic functions, while also providing research experiences for underrepresented minority STEM students.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.1m | 5/7/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
245828S | Trustees Of Boston College | Project Grant 2344561 | $78.9k | 3/24/25 |